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APC — TCF7L2

Pathways - manually collected, often from reviews:

• Reactome Reaction: TCF7L2 → APC (direct_complex)

Text-mined interactions from Literome

Wielenga et al., Am J Pathol 1999 (Adenoma...) : This suggests a link with disruption of APC tumor suppressor protein mediated regulation of beta-catenin/Tcf-4 signaling, which is crucial in initiating tumorigenesis
Huang et al., Biochem Biophys Res Commun 2009 : Constitutive activation of the transcription factor TCF4 activity by mutated APC or beta-catenin contributes to cell neoplastic transformation