Gene interactions and pathways from curated databases and text-mining

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AGTR2 — REN

Text-mined interactions from Literome

Amiri et al., J Hypertens 1999 (Disease Models, Animal...) : Renal angiotensin II receptor regulation and renin-angiotensin system inhibition in one-kidney, one clip hypertensive rats
Siragy et al., Hypertension 2005 : These data demonstrate for the first time to our knowledge that AT2 receptors regulate the renin-angiotensin system activity via inhibition of renin synthesis
Pérez-Rojas et al., American journal of physiology. Renal physiology 2005 : Spironolactone protective effect in chronic nephrotoxicity was associated with prevention of pro-renin upregulation and increased AT(2) , together with ET ( B ) reduction
Siragy et al., Am J Physiol Regul Integr Comp Physiol 2007 : NO and cGMP mediate angiotensin AT2 receptor induced renal renin inhibition in young rats ... Reversal of the PD effects by SNAP and SNAP effects by ODQ confirms that NO and cGMP mediate the AT(2) receptor inhibition of renal renin production
Yvan-Charvet et al., Endocrinology 2009 (Body Weight...) : Furthermore, despite a reduction of adipose mass in KOVEX, AT2 deficiency caused increased renin production, further worsening the hypertension caused by AGT overexpression
Böhm et al., J Hypertens 1995 (Hypertension) : The renin-angiotensin system genes in various cardiovascular organs were differentially regulated by angiotensin II receptor blockade