Ichiba et al., FEBS Lett 1999
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We demonstrated that GFR can activate Rap1 but not H-Ras in 293T cells and that the cdc25 domain of GFR is required for the activation of Rap1 Beaudry et al., Endocrinology 2006
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Treatment of cells with Gö6976 was also found to inhibit p21(ras) ( between 1-10 min ) but stimulated Rap1 activity ( 1-5 min ) in a time-course similar to that of Ang II