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AKT1 — IRS4
Text-mined interactions from Literome
Uchida et al., Mol Cell Biol 2000
:
IRS-4 mediates
protein kinase B signaling during insulin stimulation without promoting antiapoptosis ...
IRS-4 also
promoted the activation of
PKB/Akt and BAD phosphorylation during insulin stimulation ; however, it weakly bound or activated p85 associated PI 3-kinase and failed to mediate the activation of p70 ( s6k ) ...
IRS-4 also
promoted the activation of
PKB/Akt and BAD phosphorylation during insulin stimulation ; however, it weakly bound or activated p85 associated PI 3-kinase and failed to mediate the activation of p70 ( s6k )
Shimwell et al., Oncogene 2009
(Cell Transformation, Viral) :
Once expressed, as well as binding to E1A and the insulin receptor,
IRS-4 remains tyrosine phosphorylated and constitutively associates with the regulatory p85 subunit of phosphoinositide 3 kinase,
resulting in the phosphorylation of
Akt ( causing activation ) and GSK-3beta ( causing inhibition )
Chai et al., J Neuroendocrinol 2013
:
AGD3 binds with
insulin receptor substrate 4 and
increases insulin stimulated
phospho-Akt and regulates AMP activated protein kinase and mammalian target of rapamycin downstream target S6 kinase phosphorylation