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Pelegrin et al., J Biol Chem 2007
:
Inhibition of pannexin-1 blocked caspase-1 and IL-1beta processing and release in response to all three stimuli
Kanneganti et al., Immunity 2007
(Inflammation) :
Instead, caspase-1 activation required pannexin-1 , a hemichannel protein that interacts with the P2X(7) receptor
Marina-García et al., J Immunol 2008
:
Caspase-1 activation induced by MDP and ATP required pannexin-1 and Cryopyrin but was independent of Nod2
Sandilos et al., J Biol Chem 2012
:
Pannexin 1 (PANX1) channels mediate release of ATP, a `` find-me '' signal that recruits macrophages to apoptotic cells ; PANX1 activation during apoptosis requires caspase mediated cleavage of PANX1 at its C terminus, but how the C terminus inhibits basal channel activity is not understood