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CASP1 — MAP2K2
Text-mined interactions from Literome
Shiah et al., Mol Pharmacol 2001
:
Involvement of Asp-Glu-Val-Asp directed,
caspase mediated
mitogen activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel induced apoptosis in HL-60 cells
Johnson et al., Urology 2002
(Prostatic Neoplasms) :
Calcitriol induces poly ( adenosine diphosphate-ribose ) polymerase cleavage, increases bax/bcl-2 ratio, reduces levels of phosphorylated mitogen activated protein kinases ( P-MAPKs ; also known as extracellular signal related kinase [ ERK] 1/2 ) and phosphorylated Akt, induces
caspase dependent
mitogen activated protein kinase kinase ( MEK ) cleavage and upregulation of MEK kinase-1, all potential markers of the apoptotic pathway
Boileau et al., Arthritis Rheum 2002
(Osteoarthritis) :
The
ICE level is
controlled by the activation of at least 2 MAPK pathways, p38 and
MEK-1/2
Nesterov et al., Cancer Res 2004
(Cell Transformation, Neoplastic...) :
The expression of constitutively activated
mitogen activated protein kinase kinase 1
enhanced caspase 8 recruitment and sensitized immortalized human embryonic kidney cells to TRAIL induced death
Xia et al., Mol Cell 2007
:
The activation of caspase-7, which is independent of cytochrome c release and activation of caspase-9 and caspase-12, depends on activation of
caspase-8 , which in turn
requires MEK2 activity and secretion of FAS ligand
Gao et al., J Appl Physiol 2008
:
Regulation of
caspase-3 activity by insulin in skeletal muscle cells
involves both PI3-kinase and
MEK-1/2