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TP53 — TYR
Text-mined interactions from Literome
Nylander et al., J Pathol 2000
:
Transcriptional
activation of
tyrosinase and TRP-1 by
p53 links UV irradiation to the protective tanning response
Khlgatian et al., J Invest Dermatol 2002
(Melanoma) :
Tyrosinase gene expression is
regulated by
p53 ... To determine whether
p53 activation is
required for this increased
tyrosinase expression, we employed two experimental systems : ( i ) a human melanoma line ( WM35 ) known to express wild-type p53 versus WM35 cells engineered to express a transcriptionally inactive dominant negative p53 ( WM35-p53DN ) or the empty vector alone ( WM35-pCMV7 ) and ( ii ) mice with wild-type p53 versus p53 knockout mice ... Together, these data demonstrate that
p53 activation
increases tyrosinase mRNA level and subsequently pigmentation
Thangasamy et al., Cell Oncol 2008
(Melanoma, Experimental) :
Tyrosinase overexpression
promotes ATM dependent
p53 phosphorylation by quercetin and sensitizes melanoma cells to dacarbazine ... Therefore, this study demonstrates that
tyrosinase overexpression
promotes an ATM dependent
p53 phosphorylation by Qct treatment and sensitizes melanoma cells to dacarbazine
Kichina et al., Pigment Cell Res 1996
(Melanoma) :
In order to determine whether the
p53 repression of tyrosinase mRNA
involved modulation of
tyrosinase promoter activity, transient transfection approaches involving p53 expression plasmid and construct containing chloramphenicol acetyl transferase (CAT) reporter gene linked to 270 bp tissue-specific tyrosinase promoter have been used