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CDKN1A — GSK3B

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → GSK3B (directlyIncreases, CDKN1A Activity)
  Evidence: 12058028;11779850
• OpenBEL Selventa BEL large corpus: CDKN1A → GSK3B (directlyIncreases, CDKN1A Activity) Rössig et al., J Biol Chem 2002*
  Evidence: Site-directed mutagenesis revealed that GSK-3 in vitro phosphorylated p21(Cip1) specifically at Thr-57 within the Cdk binding domain.
• WikiPathways DNA Damage Response (only ATM dependent): Complex of GSK3B-APC → CDKN1A (activation)

Text-mined interactions from Literome

Chen et al., J Cell Biochem 2007 : Consequently, the inhibition of GSK-3beta decreased the nuclear factor-kappaB activity, the NF-kappaB dependent gene expression, and COX2 expression, but enhanced p21 ( WAF1/Cip1 ) transcription
Yao et al., J Cell Sci 2008 (Disease Progression...) : Thus, Fos synergism with Pten loss elicited a benign tumour context where GSK3beta induced p53/p21 WAF expression continually switched AKT associated proliferation into differentiation, preventing further progression