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FOXO1 — PPARGC1A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
PPARGC1A
—
FOXO1
(interaction, mapped from bind kegg_pathways)
-
STRING interaction:
FOXO1
—
PPARGC1A
(interaction, mapped from bind kegg_pathways)
Text-mined interactions from Literome
Southgate et al., FASEB J 2005
(Insulin Resistance) :
PGC-1alpha gene expression is
down-regulated by Akt- mediated phosphorylation and nuclear exclusion of
FoxO1 in insulin stimulated skeletal muscle
Chang et al., Endocrinology 2006
:
The expression of
PGC-1alpha in muscle is
regulated by myocyte enhancer factor 2 and
Forkhead in rhabdomyosarcoma , two transcription factors implicated in terminal muscle differentiation
Schilling et al., Nature 2006
:
Puigserver et al. show that the transcription factor FOXO1 and the transcriptional co-activator PGC-1alpha act synergistically to stimulate the expression of genes in the gluconeogenesis pathway and propose that
PGC-1alpha acts , in part, directly through
FOXO1
Hu et al., Circ Res 2008
(Disease Models, Animal...) :
Both SUR1-tg and Kir6.2 KO mice had decreased FOXO1 after transverse aortic constriction, in agreement with the reports that a decrease of
FOXO1 can
repress PGC-1alpha expression