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TNF — WAS

Text-mined interactions from Literome

Zheng et al., Int J Immunopharmacol 1992 : The present study evaluated the effect in vitro of THC on soluble TNF-alpha production by cultured murine peritoneal macrophages ... Thus, our data provide evidence that THC can inhibit TNF production by mouse and human macrophages
Li et al., Eur J Pharmacol 2013 : In the lipopolysaccharide (LPS) induced systemic inflammation model, THC significantly inhibited serum tumor necrosis factor-alpha ( TNF-a ) release in mice ... Our data demonstrated that THC significantly inhibited LPS induced TNF-a , interleukin-6(IL-6) and nitric oxide ( NO ) production ... THC inhibited the production of TNF-a and IL-6 by down regulating LPS induced IL-6 and TNF-a mRNA expression
Kusher et al., Cell Immunol 1994 : We find that these low levels of THC inhibit tumor necrosis factor-alpha (TNF) induction from LGL by C. albicans and are dependent upon THC dose ( 0.005-5.0 micrograms/ml ) and length of exposure ( 0.05-3.0 hr )
Zheng et al., Int J Immunopharmacol 1996 : The present studies have examined the mechanism of THC 's effects on tumor necrosis factor alpha (TNF-alpha) , a major macrophage produced cytokine and an important mediator involved in cytokine networks and in host defense mechanisms ... However, THC did not inhibit the levels of LPS induced TNF-alpha mRNA and intracellular TNF-alpha precursor protein, had only a weak effect on expression of membrane bound TNF-alpha, but suppressed TNF-alpha maturation/secretion by macrophages
Newton et al., Adv Exp Med Biol 1998 : It was found that THC suppressed IL-12, IL-15 and IL-6 and increased IL-1 alpha, IL-1 beta, and TNF alpha in all of the stimulated cultures