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CCL2 — IL6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IL6 → CCL2 (increases) Viedt et al., Arterioscler Thromb Vasc Biol 2002*
  Evidence: Stimulation of VSMCs with MCP-1 induced proliferation and resulted in a concentration- and time-dependent release of the proinflammatory cytokine interleukin-6 (IL-6)
• OpenBEL Selventa BEL large corpus: IL6 → CCL2 (increases)
  Evidence: Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factorkappaB and activator protein-1.

Text-mined interactions from Literome

Murao et al., FEBS Lett 1999 : In human vascular endothelial cells, interleukin-1beta and tumor necrosis factor-alpha induced endogenous monocyte chemoattractant protein-1 protein secretion, mRNA expression and promoter activity
Ishikawa et al., J Am Soc Nephrol 1999 : Bioflavonoid quercetin inhibits interleukin-1 induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB
Wu et al., Atherosclerosis 1999 : However, IL-1beta induced productions of both MCP-1 and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E. Vitamin E, at the doses used, did not significantly change the spontaneous production but dose-dependently inhibited the IL-1beta induced production of inflammatory cytokine IL-6
Coletta et al., Exp Nephrol 2000 : Selective induction of MCP-1 in human mesangial cells by the IL-6/sIL-6R complex
Akoum et al., J Clin Endocrinol Metab 2000 (Endometriosis) : Estradiol amplifies interleukin-1 induced monocyte chemotactic protein-1 expression by ectopic endometrial cells of women with endometriosis ... In the present study we report that estradiol ( E2 ) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1 induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid ( mRNA ) synthesis, whereas progesterone had no significant effects
Hess et al., J Immunol 2000 (Carcinoma in Situ...) : As a consequence of the restored IL-6 responsiveness, carcinoma cells strongly produced the chemokine monocyte chemoattractant protein-1 ( MCP-1 )
Van Lenten et al., J Biol Chem 2001 : We conclude that IL-6 is critical to short term but not long term regulation of PON and that IL-6 is not required for OXPL regulation of MCP-1
Momoi et al., Chest 2001 (Adenocarcinoma...) : In A549 cells, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha induced endogenous MCP-1 protein secretion and messenger RNA expression
Nanki et al., J Immunol 2001 (Arthritis, Rheumatoid) : In this study we show that CCL2/monocyte chemotactic protein-1, CCL5/RANTES, and CXCL12/stromal cell derived factor-1 enhanced IL-6 and IL-8 production by fibroblast-like synoviocytes ( FLS ) from patients with RA, and their corresponding receptors, CCR2, CCR5, and CXCR4, respectively, were expressed by RA FLS
Viedt et al., J Am Soc Nephrol 2002 (Nephritis) : MCP-1 stimulated interleukin-6 (IL-6) secretion and intercellular adhesion molecule-1 ( ICAM-1 ) synthesis in a time- and dose dependent manner ... In parallel, MCP-1 increased IL-6 and ICAM-1 mRNA expression in human TECs ... Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1 dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca ( 2+ ), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling ... In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1 mediated induction of IL-6 , as demonstrated by cis element double stranded ( decoy ) oligonucleotides ( ODN )
Viedt et al., Arterioscler Thromb Vasc Biol 2002 (Inflammation) : Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-kappaB and activator protein-1 ... Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1 dependent IL-6 release, suggesting the involvement of G ( i ) proteins, protein kinase C, and nuclear factor-kappaB (NF-kappaB)
Tofaris et al., J Neurosci 2002 (Neurilemmoma) : Furthermore, IL-6 rapidly induced LIF mRNA in primary Schwann cells, and LIF rapidly induced MCP-1 mRNA expression
Arendt et al., Leukemia 2002 (Multiple Myeloma) : Interleukin 6 induces monocyte chemoattractant protein-1 expression in myeloma cells ... Moreover, we also demonstrated IL-6 stimulated MCP-1 secretion by the myeloma cell lines as well as by fresh patient tumor cells
Matagrano et al., In Vitro Cell Dev Biol Anim 2003 : Finally, the enhancing effect of TGF-beta1 on MCP-1 secretion was not due to IL-6
Rott et al., Atherosclerosis 2003 (Arteriosclerosis...) : IL-6 is produced by splenocytes derived from CMV infected mice in response to CMV antigens, and induces MCP-1 production by endothelial cells : a new mechanistic paradigm for infection induced atherogenesis ... IL-6 induced , in a dose response fashion, MCP-1 expression in human ECs : 0, 2, 10, and 50 pg/ml IL-6 increased MCP-1 levels in EC conditioned medium from 1120+/-65 to 1148+/-105, 1395+/-40, and 2119+/-130 pg/ml, respectively ( P < 0.001 ) ... IL-6 also induced MCP-1 expression in mouse ECs ( P < 0.002 )
Fasshauer et al., Biochem Biophys Res Commun 2004 : Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes ... Studies using pharmacological inhibitors suggested that the positive effects of GH and IL-6 on MCP-1 synthesis are at least in part mediated by janus kinase 2 and p44/42 mitogen activated protein kinase
Watanabe et al., Am J Nephrol 2004 (Arteriosclerosis) : One mechanism likely involves direct effects of IL-6 on vascular smooth muscle cells ( VSMC ), for IL-6 can induce VSMC proliferation and the release of monocyte chemoattractant protein-1 ( MCP-1 ) ... The JAK/STAT pathway partially mediates IL-6 induced MCP-1 production and DNA synthesis in rat VSMC
Elhofy et al., J Leukoc Biol 2005 (Encephalomyelitis, Autoimmune, Experimental) : Overexpression of CCL2 in the CNS resulted in decreased interleukin-12 receptor expression by antigen-specific T cells
Skrabal et al., J Surg Res 2005 (Brain Death) : MCP-1 and TGF-beta were significantly higher in heart and lung and IL-6R increased in heart after brain death ( P < 0.05 )
Lee et al., Toxicological sciences : an official journal of the Society of Toxicology 2005 : In iAs treated rVSMCs, catalase, dimethylsulfoxide, and L-omega-nitro-L-arginine significantly inhibited the increase in expression of all three genes, allopurinol inhibited the increase in MCP-1 and IL-6 expression, but had no effect on HO-1 expression, while superoxide dismutase had no significant effect on HO-1 expression, but had an inhibitory effect on IL-6 expression and a stimulatory effect on MCP-1 expression
Yamamoto et al., Toxicol Appl Pharmacol 2006 (Pneumonia) : LTA produced a dose related increase in early pulmonary inflammation, which was characterized by ( 1 ) influx of polymorphonuclear neutrophils ( PMNs ) and ( 2 ) induction of interleukin (IL)-6 , tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha/CCL3, but no effect on monocyte chemoattractant protein (MCP)-1/CCL2 at 24 h after instillation
Bouchelouche et al., J Urol 2006 : Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1 , IL-6 and SCF
Holven et al., Scand J Clin Lab Invest 2006 (Cardiovascular Diseases...) : IL-6 increased the release of monocyte chemoattractant protein-1 from peripheral blood mononuclear cells, with particularly enhancing effects in cells from patients with hyperhomocysteinemia
Chen et al., Br J Pharmacol 2006 : Furthermore, Mag suppressed IL-6 induced promoter activity of cyclin D1 and monocyte chemotactic protein (MCP)-1 for which STAT3 activation plays a role
Morimoto et al., Circ Res 2006 (Cardiomegaly...) : Our results suggest that cardiac overexpression of MCP-1 induced macrophage infiltration, neovascularization, myocardial IL-6 secretion, and accumulation of cardiac myofibroblasts, thereby resulting in the prevention of LV dysfunction and remodeling after MI
Sharma et al., Am J Physiol Lung Cell Mol Physiol 2007 (Inflammation...) : H/R ( 3 h/1 h ) significantly induced KC, MCP-1, macrophage inflammatory protein-2 ( MIP-2 ), RANTES, and IL-6 ( but not TNF-alpha ) by MLE-12 cells, whereas H/R induced TNF-alpha, MCP-1 , RANTES, MIP-1alpha, and MIP-2 ( but not KC ) by RAW264.7 cells
Suzuki et al., Rheumatol Int 2010 (Arthritis) : IL-6 and IL-6 + sIL-6R induced production of both MCP-1 and IL-8 in PBMC and synovial cells, respectively ... In HUVEC, IL-6 + sIL-6R induced MCP-1 production, but inhibited IL-8 production
Strassheim et al., J Immunol 2009 : We found that iloprost inhibited IFN-gamma- and IL-6 induced MCP-1 , IL-8, RANTES, and TNF-alpha production in monocytes, indicating wide ranging anti-inflammatory action
Maekawa et al., J Vasc Res 2010 : Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the upregulation of early growth response-1 transcription in human coronary artery endothelial cells
Wu et al., J Gen Virol 2010 (Adenoviridae Infections...) : The results showed that IL-8 and IL-6 were induced 8 h after infection and, by 24 h, levels of IL-8, IL-6, MIP-1alpha/beta and MCP-1 were all increased
Jougasaki et al., Br J Pharmacol 2010 : Statins suppress interleukin-6 induced monocyte chemo-attractant protein-1 by inhibiting Janus kinase/signal transducers and activators of transcription pathways in human vascular endothelial cells ... We investigated the effects of statins on interleukin (IL)-6 induced monocyte chemo-attractant protein (MCP)-1 expression and monocyte chemotaxis ... IL-6 plus its soluble receptor sIL-6R ( IL-6/sIL-6R ) promoted THP-1 monocyte migration, and increased gene expression and protein secretion of MCP-1 , more than IL-6 alone or sIL-6R alone ... Geranylgeranyl transferase inhibitor, but not farnesyl transferase inhibitor, suppressed IL-6/sIL-6R stimulated MCP-1 expression ... Statins suppressed IL-6/sIL-6R induced monocyte chemotaxis and MCP-1 expression in HAECs by inhibiting JAK/STAT signalling cascades, explaining why statins have anti-inflammatory properties beyond cholesterol reduction
Fukushima et al., J Endod 2010 : IL-1beta and IL-6 simultaneously induced IL-8 and monocyte chemoattractant protein-1 secretion in PDL cells, whereas SOCS-3 overexpression suppressed secretion of these chemokines through inhibition of phosphorylation in downstream signaling
Yin et al., BMC immunology 2010 : HBD2 significantly induced IL-6 , while hBD3 induced MCP-1 to approximately the same extent as LPS, suggesting a unique role in immune responses
Villarroya et al., Antivir Ther 2010 (Disease Models, Animal...) : Gene expression of monocyte chemoattractant protein-1 was induced in visceral and subcutaneous fat, whereas tumour necrosis factor-a and interleukin-6 were induced in visceral and subcutaneous white adipose tissues, respectively
Darisipudi et al., Am J Pathol 2011 (Diabetes Mellitus, Type 2...) : CCL2 blockade reduced glomerular leukocyte counts and renal-inducible nitric oxide synthase or IL-6 mRNA expression
Lai et al., Int J Gynecol Cancer 2011 (Genital Neoplasms, Female...) : Similar treatment in HeLa cells caused increases in the mRNA levels of CCL2 , CXCL2, IL-6, and IL-8, and in SKOV3 cells, mRNA levels of CCL2, CCL20, CXCL1, CXCL2, IL-6 , and IL-8 increased
Strecker et al., PloS one 2011 (Brain Ischemia) : Monocyte chemoattractant protein-1-deficiency impairs the expression of IL-6 , IL-1ß and G-CSF after transient focal ischemia in mice
McClellan et al., Cytokine 2012 (Adenomatous Polyposis Coli...) : Gene expression ( mRNA ) of MCP-1 , IL-1ß, IL-6 and TNF-a was increased in sections 2 and 3 starting at week 12 ( P < 0.05 ), with further increases in MCP-1, IL-1ß and IL-6 at 16 weeks ( P < 0.05 )
Hashizume et al., Eur J Pharmacol 2012 (Arthritis, Rheumatoid) : Both a-IL-6R Ab and TNFR-Fc partially inhibited this MCP-1 production
Mehta et al., Journal of translational medicine 2012 (Inflammation...) : Adipose tissue mRNA levels of IL-6 ( peak 6-fold, ANOVA F = 27.5, p < 0.001 ) and TNF-alpha ( peak 1.8-fold, F = 2.9, p = 0.01 ) increased with MCP-1 ( peak 10-fold, F = 5.6, p < 0.01 ) and fractalkine ( CX3CL1 ) ( peak 15-fold, F = 13.3, p < 0.001 )
Timper et al., Am J Physiol Endocrinol Metab 2013 (Insulin Resistance) : GIP induced mRNA expression of IL-6 , IL-1ß, and the IL-1 receptor antagonist IL-1Ra, whereas TNFa, IL-8, and monocyte chemotactic protein (MCP)-1 remained unchanged
Zhang et al., J Biol Chem 2013 : In vitro, IL-6 deficiency or Signal Transducer and Activator of Transcription 3 ( STAT3 ) knockdown in activated macrophage attenuated the expression of CCL2 , CCL3, but not CCL5, which resulted in less macrophage migration
Tom et al., Eur J Cell Biol 2013 (Inflammation) : Treatment with ASP for 24h increased monocyte chemoattractant protein-1 ( MCP1, 800 %, P < 0.001 ) and keratinocyte derived chemokine ( KC, > 150 %, P < 0.01 ) secretion in adipocytes in a dose dependent manner, with no effect on IL-6 or adiponectin
Lee et al., Int Immunol 2013 : Furthermore, human lung epithelial cells expressed CCL2 after stimulation by IFN? in the presence of IL-6 and epidermal growth factor via enhanced STAT3 signaling, which parallels behavior seen in the mouse model
Burel et al., Nucleic acid therapeutics 2013 : In mice, the alterations at 70 mg/kg/week included spleen weight increase up to 1.4-fold relative to control, increases in alanine aminotransferase and aspartate aminotransferase up to 1.8-fold over control, interleukin-10 increases up to 3.7-fold, and monocyte chemoattractant protein-1 increase up to 1.9-fold over control
Kim et al., Mol Med Report 2013 : Monocyte chemotactic protein-1 (MCP-1)/CCL2, interleukin (IL)-6 and IL-8 increased following DpE treatment and arazyme significantly blocked the increase of MCP-1 , IL-6 and IL-8 expression in cell types
Selenica et al., Journal of neuroinflammation 2013 : The protein expression profile in the hippocampus demonstrated markedly increased levels of IL-6 , GM-CSF and eotaxin ( CCL-11 ) in response to CCL2 , but no changes in the levels of other cytokines, including TNF-a and IFN-?
Goppelt-Struebe et al., FEBS Lett 1995 : Synergistic induction of monocyte chemoattractant protein-1 ( MCP-1 ) by platelet derived growth factor and interleukin-1
Hayashi et al., J Neuroimmunol 1995 : Lipopolysaccharide (LPS), interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha induced MCP-1 secretion by astrocytes, but not microglia
Zhu et al., J Bone Miner Res 1994 : The effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) , transforming growth factor beta ( TGF-beta ), platelet derived growth factor ( PDGF-BB ), parathyroid hormone (PTH), and 1,25 ( OH ) 2D3 on MCP-1 expression in human osteoblastic cells were compared ... At the mRNA level, IL-1 beta and TNF-alpha strongly induced MCP-1 expression ; TGF-beta and IL-6 induced MCP-1 but to a lesser extent
Colotta et al., Am J Pathol 1994 : Induction of MCP-1 transcript by thrombin was not reduced by blocking interleukin-1 and tumor necrosis factor, suggesting that these mediators are not involved in thrombin induced expression of MCP-1
Hanazawa et al., Infect Immun 1993 (Periodontal Diseases) : The MCP-1 gene expression was induced in the fibroblasts treated with interleukin-1 beta and tumor necrosis factor alpha, but not with interleukin-6
Bodine et al., Endocrinology 1996 : Finally, interleukin-1 beta and tumor necrosis factor-alpha ( 1-1000 pM ) stimulated dose dependent increases in the secretion of interleukin-6 and monocyte chemoattractant protein-1 at 34 C and 40C
Hartner et al., Kidney Int 1997 : While LIF as well as IL-6 up-regulated monocyte chemotactic protein-1 (MCP-1) mRNA expression, OsM showed no such effect ... The rapid, transient and differential regulation of MCP-1 expression induced by LIF and IL-6 contrasted with uniformly powerful effects of the proinflammatory cytokines IL-1 beta and TNF alpha that induced all tested chemokines for prolonged time periods ... These results suggest that the selective and transient induction of MCP-1 by LIF and IL-6 may play a role in the preferential attraction of monocytes to the injured glomerulus
Biswas et al., Blood 1998 (HIV Infections...) : Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line ... In addition, because human immunodeficiency virus ( HIV ) infection in vivo and in vitro has been shown to dysregulate the production of and/or the response to cytokines, PBMCs from both healthy uninfected and HIV infected individuals were studied for their constitutive and IL-6 induced expression of MCP-1 ... In these cell lines, IL-6 selectively induced MCP-1 and not other chemokines, including regulated upon activation normal T cells expressed and secreted ( RANTES ), macrophage inflammatory protein-1alpha ( MIP-1alpha ), MIP-1beta, and IL-8 ... IL-6 induction of MCP-1 was partially inhibited by hydrocortisone in U1 cells