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EPHB2 — SHH

Text-mined interactions from Literome

Osawa et al., Biochem Biophys Res Commun 2006 (MAP Kinase Signaling System) : In addition, Shh as well as calcium ionophore A32187 rapidly activated ERK ... On the other hand, although Shh induced Gli-1 nuclear accumulation in RGM-1 cells, Shh activated ERK even in cells pretreated with actinomycin D
Fogarty et al., Proc Natl Acad Sci U S A 2007 (Neoplasms) : FGF mediated inhibition of Shh responses requires activation of FGF receptors and of ERK and JNK kinases, because it can be blocked by inhibitors of these enzymes
Spence et al., Dev Dyn 2007 : We examined early signaling events in the CB/CMZ and found that FGF2 or Shh induced a robust Erk phosphorylation during the early stages of retina regeneration
Elia et al., Biochim Biophys Acta 2007 : Most importantly, we report that Shh induces MAPK/ERK and phosphoinositide 3-kinase (PI3K) dependent Akt phosphorylation and that activation of both signaling pathways is essential for Shh 's signaling in muscle cells
Chang et al., Int J Biochem Cell Biol 2010 : Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling
Singh et al., J Biol Chem 2012 (Pancreatic Neoplasms) : CXCL12 induced SHH up-regulation is specifically mediated through the receptor CXCR4 and is dependent on the activation of downstream Akt and ERK signaling pathways