Zhen et al., Mol Pharmacol 2001
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In contrast, the transfection of N17Ras into D ( 4 ) MN9D cells blunted D(4) dopamine receptor mediated ERK activation , indicating a Ras dependent mechanism ... All these indicate that distinct mechanisms mediate ERK and Akt/NF-kappa B activation by D(4) dopamine receptor stimulation
Gill et al., Cell Signal 2010
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The DRD4 mediated ERK1/2 response was only partially blunted by PDGF-BB mediated downregulation, but remained sensitive to the PDGFRbeta kinase inhibitor tyrphostin A9