Namkoong et al., Diabetes 2005
(Diabetes Mellitus, Experimental...) :
Chronic insulin treatment or suppression of hypothalamic AMPK activity completely prevented diabetes induced changes in food intake as well as in hypothalamic AMPK activity and mRNA expression of neuropeptide Y and proopiomelanocortin Chau-Van et al., Endocrinology 2007
:
Proopiomelanocortin gene expression measured in parallel was inhibited under low glucose conditions, but in contrast to NPY, it was not dependent upon AMPK and not affected by metformin
Ropelle et al., Diabetes 2008
(Weight Loss) :
Leucine and HPD decrease AMPK and increase mTOR activity in the hypothalamus, leading to inhibition of neuropeptide Y and stimulation of pro-opiomelanocortin expression