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FOS — TRAF6
Text-mined interactions from Literome
Funakoshi et al., Int Immunopharmacol 2001
:
These observations were prominent particularly in the TRAF6 transfection system, in which overexpression of wild type
TRAF6 augmented the IL-1 mediated NF-kappa B and
AP-1 activation, while dominant negative TRAF6 construct ( delta TRAF6 ) suppressed these activation ... Namely, LY294002 inhibited
TRAF6 mediated IL-1 induced NF-kappa B and
AP-1 activation markedly, while SB203580 inhibited TRAF6 induced AP-1 activation but not NF-kappa B activation
Funakoshi-Tago et al., Eur J Biochem 2003
:
TRAF6 and C-SRC
induce synergistic
AP-1 activation via PI3-kinase-AKT-JNK pathway ... We found that IL-1 mediated c-Src activation was required for AP-1 activation, but not for NF-kappa B activation and also revealed that c-Src induced
AP-1 activation was
enhanced synergistically by the coexpression of
TNF receptor associated factor 6 (TRAF6)
Wang et al., Nat Immunol 2006
:
Formation of the beta-arrestin-TRAF6 complex prevented autoubiquitination of
TRAF6 and
activation of NF-kappaB and
AP-1