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CCL2 — NFKB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Rovin et al., Cytokine 1999
:
Because
NF-kappaB is
necessary for
MCP-1 gene expression, the effect of p38 kinase inhibition on IL-1beta induction of NF-kappaB was measured ... PD 098059, a selective inhibitor of the ERK activating kinase MEK1, had no effect on IL-1beta induced
MCP-1 mRNA or protein levels, or on IL-1beta
activation of
NF-kappaB
Fujita et al., Nihon rinsho. Japanese journal of clinical medicine 1999
(Diabetic Angiopathies...) :
In macroangiopathy, AGE plays an important role in atherogesis through
NF-kappa B activation, that
induces VCAM-1 and
MCP-1
Wang et al., J Am Soc Nephrol 1999
:
Therefore, albumin increased NFkappaB and reduced IkappaB levels in PTC, and
MCP-1 expression was
dependent on
NFkappaB activation
Desai et al., Lab Invest 1999
(Disease Models, Animal...) :
Because in vitro expression of
MCP-1 is in part
mediated by the redox-sensitive transcription factors
nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1), we studied their activation as a function of varying intracellular GSH redox status in the pathogenesis of glucan induced pulmonary granulomatosis
Ishikawa et al., J Am Soc Nephrol 1999
:
These results suggest that : ( 1 ) quercetin has the ability to attenuate activation of
NF-kappaB ; and ( 2 ) it
inhibits IL-1 triggered
MCP-1 expression via suppression of NF-kappaB, but not AP-1, in glomerular cells
Wang et al., Kidney Int 2000
:
These studies prove that
NF-kappaB is
critical for LPS induced
MCP-1 transcription, and AP-1 and Sp1 are essential for basal expression of MCP-1 in rat tubule cells
Molestina et al., Infect Immun 2000
(Arteriosclerosis) :
Requirement for
NF-kappaB in transcriptional activation of
monocyte chemotactic protein 1 by Chlamydia pneumoniae in human endothelial cells ... To examine the underlying mechanisms by which C. pneumoniae infection induces MCP-1 production in endothelial cells, the present study investigated the
role of transcription factor
NF-kappaB in
MCP-1 mRNA expression
Rimbach et al., Mol Cell Biol Res Commun 2000
:
Macrophages stimulated with IFN-gamma activate
NF-kappa B and
induce MCP-1 gene expression in primary human endothelial cells
Brenier-Pinchart et al., Mol Cell Biochem 2000
:
We also found that
MCP-1 secretion induced by live T. gondii is
blocked by inhibitors of
nuclear factor (NF)-kappaB activation, ALLN and MG132 ... Such data indicate that
NF-kappaB could be
involved in T. gondii induced
MCP-1 production
Iseki et al., Biochem Biophys Res Commun 2000
:
These results indicate that TNF-alpha dependent expression of
MCP-1 in HASMC is tightly
regulated by
NF-kappaB and that intracellular copper level is crucial for the TNF-alpha dependent activation of NF-kappaB in HASMC
Goebeler et al., Blood 2001
:
Multiple signaling pathways regulate
NF-kappaB dependent transcription of the
monocyte chemoattractant protein-1 gene in primary endothelial cells ... NiCl ( 2 ) -induced
MCP-1 synthesis
required activation of
NF-kappaB since mutation of NF-kappaB binding sites in the promoter resulted in complete loss of inducible promoter activity
Cho et al., Infect Immun 2001
:
The induction of
MCP-1 and IL-8 transcripts in the endothelial cells by O. tsutsugamushi was not
blocked by the inhibitors of
NF-kappaB
Mori et al., Infect Immun 2001
:
Induction of
monocyte chemoattractant protein 1 by Helicobacter pylori
involves NF-kappaB
Lucio-Cazana et al., J Am Soc Nephrol 2001
:
Experiments that used pharmacologic and genetic inhibitors showed that the IL-1beta-inducible
MCP-1 expression was
dependent on
nuclear factor-kappaB (NF-kappaB) and independent of activator protein 1 (AP-1) ... In contrast, the constitutive expression of
MCP-1 was
dependent on both
NF-kappaB and AP-1 ... These data suggested that ( 1 ) constitutive and IL-1beta-inducible expression of MCP-1 was differently regulated by AP-1 and
NF-kappaB and ( 2 ) t-RA
inhibited selectively the constitutive expression of
MCP-1 via intervention in the AP-1 pathway
Kraft et al., Int Arch Allergy Immunol 2001
(Hypersensitivity, Immediate) :
Inhibitors of
NF-kappa B activation such as N-acetylcysteine or N-tosyl-L-phenylalanine chloromethyl ketone can
suppress Fc epsilon RI-induced TNF-alpha and
MCP-1 release
Galindo et al., Arthritis Rheum 2001
(Scleroderma, Systemic) :
Increased
NF-kappaB or AP-1 activation was not
responsible for the constitutive overexpression of
MCP-1 by SSc fibroblasts
Kim et al., Parasitol Res 2001
(Toxoplasmosis) :
These results suggest that
NF-kappaB is a central regulator of the chemokine response in T. gondii infected human epithelial cells and that chemokine IL-8 and
MCP-1 secretion might be
involved in the pathogenesis of T. gondii, via the recruitment of neutrophils, monocytes, and lymphocytes
Lakshminarayanan et al., Am J Pathol 2001
(Ischemia) :
These results suggest that reactive oxygen intermediate generation, after a brief ischemic episode, is capable of
inducing MCP-1 expression in venular endothelium through AP-1 and
NF-kappaB
López-Urrutia et al., Biochem Biophys Res Commun 2001
(Brucellosis...) :
For this purpose, the induction of cyclooxygenase-2 (COX-2), the production of the chemokine
monocyte chemoattractant protein-1 ( MCP-1 ), and the
activation of the
nuclear factor kappa B (NF-kappa B) were studied
Okuno et al., Scand J Gastroenterol 2002
:
The inhibition of
NF-kappaB activation markedly
blocked both IL-1beta- and TNF-alpha induced IL-8 and
MCP-1 mRNA expression, but did not affect MMP-1 mRNA expression
Carpenter et al., BMC infectious diseases 2002
(Lung Neoplasms) :
In this study, we examined the
NF-kappaB mediated effects of RSV and the proinflammatory cytokine TNFalpha on the induction of IL-8,
MCP-1 and RANTES chemokine gene expression in A549 epithelial cells
Viedt et al., J Am Soc Nephrol 2002
(Nephritis) :
Using electrophoretic gel mobility shift assay, we observed that
MCP-1 stimulated binding activity of
NF-kappaB
Viedt et al., Arterioscler Thromb Vasc Biol 2002
(Inflammation) :
MCP-1 stimulated the binding activity of
NF-kappaB and of activator protein-1 (AP-1) ... The results clearly demonstrate that
MCP-1 induces differential activation of
NF-kappaB and AP-1 in VSMCs
Zimmerman et al., Am J Physiol Regul Integr Comp Physiol 2002
(Carotid Artery Injuries...) :
Expression of the
NF-kappaB dependent cytokine
monocyte chemotactic protein 1 was markedly diminished in injured TNF ( -/- ) animals
Zoja et al., Kidney Int 2002
(Hemolytic-Uremic Syndrome) :
Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via
NF-kappaB dependent up-regulation of IL-8 and
MCP-1
Cho et al., Infect Immun 2002
(Scrub Typhus...) :
Although NF-kappaB activation was observed in HUVEC infected with O. tsutsugamushi, inhibition of
NF-kappaB activation did not
affect the
MCP-1 expression
Oda et al., J Immunol 2002
:
Although
NF-kappaB is
involved in regulating the IL-1alpha induced expression of
MCP-1 and IL-8, the degradation of IkappaB-alpha stimulated by IL-1alpha was not inhibited by alprazolam
Sung et al., Kidney Int 2002
(Reperfusion Injury) :
Enhanced
MCP-1 expression during ischemia/reperfusion injury is
mediated by oxidative stress and
NF-kappaB ... Pretreatment of rats with NF-kappaB inhibitors not only prevented
NF-kappaB activation induced by ischemia/reperfusion, but also
inhibited MCP-1 mRNA expression ... The present study clearly demonstrates that enhanced
MCP-1 expression in rat kidney during ischemia/reperfusion injury is
mediated by
NF-kappaB activation and oxidative stress
Krishnaswamy et al., Frontiers in bioscience : a journal and virtual library 2003
(Leukemia, Mast-Cell) :
The
NF-kappaB inhibitor, Bay-11,
inhibited expression of
MCP-1
Brueckmann et al., Thromb Haemost 2003
:
Electrophoretic mobility shift assays revealed that APC attenuated NF-kappaB DNA binding capacity implying that
NF-kappaB may not be
involved in the upregulatory effect of APC on
MCP-1 production
Bian et al., Exp Eye Res 2003
(Translocation, Genetic) :
This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and
NF-kappaB inducing kinase signaling pathways for hRPE IL-8 and
MCP-1 secretion induced in hRPE by co-culture with monocytes ... These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of
NF-kappaB , PKC, and PTK are
essential for IL-8 and
MCP-1 expression by hRPE cells
Wuyts et al., Respir Med 2003
(Asthma...) :
We conclude that p38 MAPK, JNK kinase, ERK and
NF-kappaB are
involved in the IL-1beta induced eotaxin,
MCP-1 , and MCP-3 expression and release in HASMC
Li et al., Chin Med J (Engl) 2003
:
mRNA expression of proinflammatory cytokines ( IL-1 beta, IL-6, TNF-alpha, and
MCP-1 ) and
activation of
NF-kappa B of HMC were measured using Reverse transcription-polymerase chain reaction ( RT-PCR ) and electrophoretic mobility shift assay ( EMSA ) respectively
Wu et al., Mol Endocrinol 2004
:
Ang II stimulation
induced MCP-1 mRNA expression as well as an increase in nuclear factor-kappaB (NF-kappaB) binding to the corresponding cis DNA element of the MCP-1 promoter region and a decrease in the cytosolic inhibitory protein-kappaB ( IkappaB ) protein level via AT(1) receptor stimulation, whereas stimulation of the AT(2) receptor decreased Ang II-induced MCP-1 expression,
NF-kappaB DNA binding, and IkappaB degradation, suggesting that activation of the AT(2) receptor attenuated AT(1) receptor mediated MCP-1 expression via a decrease in NF-kappaB DNA binding and an increase in IkappaB stability
Matsuyama et al., J Immunol 2004
:
In this study, we report that the interaction of DDR1b with collagen up-regulates the production of IL-8, macrophage inflammatory protein-1alpha, and
monocyte chemoattractant protein-1 in human macrophages in a p38 MAPK- and
NF-kappaB dependent manner
Zafiriou et al., Kidney Int 2004
(Fibrosis...) :
LDL induced increases in
MCP-1 and TGF-beta1 were
independent of
nuclear factor-kappaB (NF-kappaB) transcriptional activity
Kato et al., J Am Soc Nephrol 2004
(Peritonitis) :
These show that TLR4 is directly involved in the production of
MCP-1 and MIP-2 by MPMC in a
NF-kappaB dependent manner, but the process does not require any MAP kinase activation
Huang et al., Arterioscler Thromb Vasc Biol 2004
:
The
NF-[kappa]B activation may be
involved in LTB4 increased
MCP-1 expression
Zheng et al., J Huazhong Univ Sci Technolog Med Sci 2004
(Pancreatitis) :
The activity of NF-kappaB in pancreatic acinar cells was significantly increased ( P < 0.01 ) after treated with M3 cholinergic receptor agonist ( 10 ( -3 ) mol/L carbachol ) in vitro for 30 min. Either M3 cholinergic receptor antagonist ( 10 ( -5 ) mol/L atropine ) or NF-kappaB inhibitor ( 10 ( -2 ) mol/L PDTC ) could obviously inhibit the
activation of
NF-kappaB and the chemokine MOB-1,
MCP-1 mRNA expression induced by carbachol ( P < 0.05 )
Lin et al., J Immunol 2005
:
The expression of IL-6, IL-8, and
MCP-1 was
blocked by the preabsorption of anti-DV NS1 with DV NS1 or by the inhibition of
NF-kappaB activation
Zeng et al., Acta Pharmacol Sin 2005
:
Inhibitors of PKC ( calphostin C, 50-500 nmol/L and RO-31-8220, 10-100 nmol/L ), CaM ( W7, 28-280 micromol/L ), ERK1/2 MAPK ( PD 98059, 2-20 micromol/L ), p38 MAPK ( SB 203580, 0.6-6 micromol/L ), JNK MAPK ( curcumin, 2-10 micromol/L ), and
NF-kappaB ( PDTC, 10-100 nmol/L ) markedly reduced Hcy 100 micromol/L induced production of MCP-1 and IL-8 in human cultured whole blood, but the inhibitors of PTK ( genistein, 2.6-26 micromol/L and tyrphostin, 0.5-5 micromol/L )
had no obvious effect on
MCP-1 and IL-8 production
Gruden et al., J Am Soc Nephrol 2005
:
Stretch activated the IkappaB-NF-kappaB pathway, and NF-kappaB inhibition, with the use of the specific inhibitor SN50, completely abolished stretch induced MCP-1, indicating that stretch induced
MCP-1 was
NF-kappaB dependent
Fritz et al., J Orthop Res 2005
(MAP Kinase Signaling System) :
Particulate wear debris
induced NF-kappaB activation, the major transcriptional regulator of IL-8 and
MCP-1 pro-inflammatory genes and, indeed, both IL-8 and MCP-1 chemokine gene expressions were upregulated in titanium particulate stimulated human osteoblasts
McCord et al., Infect Immun 2005
:
However,
MCP-1 production was
dependent on
NF-kappaB activity
Tanifuji et al., Antioxid Redox Signal 2005
:
AngII induced
MCP-1 protein expression in mProx at 6 h was largely
blocked by ROS ( N-acetylcysteine ; 82 +/- 14 % ), Ras ( N-acetyl-S-trans, trans-farnesyl-L-cysteine ; 82 +/- 13 % ), and
nuclear factor-kappaB (NF-kappaB) ( parthenolide ; 89 +/- 7.9 % ) inhibitors ... In MC, protein kinase ( calphostin C ; 84 +/- 2.8 % ) and
NF-kappaB ( 89 +/- 1.4 % ) inhibitors
attenuated acute AngII induced
MCP-1 expression stronger than ROS/Ras inhibitors ( 1.0 +/- 0.9/29 +/- 9.5 % )
Matsuyama et al., Am J Respir Cell Mol Biol 2005
(Sarcoidosis, Pulmonary) :
The inhibitor of
NF-kappaB inhibited the production of
MCP-1 and MMP-9
Lawrence et al., Glia 2006
(AIDS Dementia Complex...) :
Electromobility shift assays ( EMSAs ) demonstrated increased nuclear NF-kappaB levels within 2 h of initiating astrocyte differentiation, and inhibitors of
NF-kappaB activation partially
blocked the
CCL2 increase in differentiating astrocytes ... Together these results suggest that the transcription factor
NF-kappaB , and possibly NF-I,
contribute to the upregulation of
CCL2 chemokine production during the differentiation of human progenitor cells toward an astrocyte phenotype
Gu et al., Nephrol Dial Transplant 2006
:
NF-kappaB and Sp1
regulate MCP-1 gene transcription
Pontrelli et al., J Am Soc Nephrol 2006
:
On the contrary,
NF-kappaB inhibition significantly
reduced only
MCP-1 expression
Calkin et al., Diabetologia 2006
(Atherosclerosis...) :
In addition, gemfibrozil reduced the expression of the genes encoding nuclear factor kappa B (NF-kappaB) subunit, p65, the
NF-kappaB dependent chemokine
monocyte chemoattractant protein-1 , and tissue factor
Matsuo et al., Kidney Int 2006
(Fibrosis) :
Although glucose increased phosphorylation of MEK1/2, p42/44 MAPK, p38 MAPK, JNK1/2, and PKC, and DNA binding activity of NF-kappaB, its effect on
MCP-1 expression was
suppressed only by PKC and
NF-kappaB inhibitors
Han et al., J Am Soc Nephrol 2006
(Diabetes Mellitus, Type 2...) :
In addition, aldosterone induced upregulation of MCP-1 expression and
NF-kappaB transcriptional activity in cultured cells, and spironolactone
reduced both NF-kappaB activation and
MCP-1 synthesis
Franchi et al., Nat Immunol 2006
(Salmonella Infections) :
Here we demonstrate that salmonella strains either lacking flagellin or expressing mutant flagellin were deficient in activation of caspase-1 and in interleukin 1beta secretion, although transcription factor
NF-kappaB dependent production of interleukin 6 or the chemokine
MCP-1 was unimpaired
Nozell et al., J Immunol 2006
(Astrocytoma) :
IFN-gamma-inducible protein-10 and
MCP-1 genes, also
regulated by
NF-kappaB , are unaffected by IFN-beta, and IFN-beta does not prevent the activation, nuclear migration, or binding of NF-kappaB p65 to the kappaB element of the IFN-gamma-inducible protein-10 promoter
Butler et al., J Biol Chem 2006
:
In this report we have shown that elafin
inhibits the lipopolysaccharide induced production of
monocyte chemoattractant protein-1 in monocytes by inhibiting AP-1 and
NF-kappaB activation
Komine et al., Mol Immunol 2007
(Periodontitis) :
Con A low-affinity saliva Lf peptides, PR3 treated Lf preparation and two of four synthetic polypeptides induced the production of interleukin IL-6,
monocyte chemoattractant protein-1 and IL-8, and the
activation of
NF-kappaB in human oral epithelial HSC-2 cells
Hernández-Vargas et al., Circ Res 2006
(Atherosclerosis) :
Furthermore, the expression of
monocyte chemoattractant protein-1 ( MCP-1 ), RANTES ( Regulated on Activated Normal T-cell Expressed and Secreted ), and intercellular adhesion molecule-1 ( ICAM-1 ) and the
activation of
nuclear factor-kappaB (NF-kappaB) were significantly reduced in aortic lesions from DKO mice
Zaidi et al., Immunology 2006
:
In contrast, inhibitors of
nuclear factor kappa B (NF-kappaB) completely
blocked CCL2 production in MLMC and BMMC but not in LAD 2 mast cells
Riccioli et al., J Immunol 2006
:
Moreover, we studied the
role of
NF-kappaB and of MAPKs in regulating TLR mediated
MCP-1 secretion by using inhibitors specific for each transduction pathway and we demonstrated a pivotal role of the IkappaB/NF-kappaB and JNK systems
Moon et al., Infect Immun 2007
(Acute Disease...) :
Toll-like receptor 2-dependent
NF-kappaB activation is
involved in nontypeable Haemophilus influenzae induced
monocyte chemotactic protein 1 up-regulation in the spiral ligament fibrocytes of the inner ear
Amin et al., Arthritis Rheum 2007
(Arthritis, Rheumatoid) :
Additionally, RA ST fibroblast IL-18 induced
MCP-1/CCL2 production was
mediated by JNK, PI3K, and
NFkappaB
Vaziri et al., J Pharmacol Exp Ther 2007
(Disease Models, Animal...) :
The untreated group exhibited hypertension, deterioration of renal function and structure, reduced or unchanged plasma renin activity, aldosterone concentration, marked up-regulations of AT1r ( 250 % ), Ang II-expressing cell count ( > 20-fold ), NAD ( P ) H oxidase subunits ( gp91(phox,) p22(phox), and P47 ( phox ) ; 20-40 % ), COX-2 ( 250 % ), 12-lipooxygenase ( 100 % ),
MCP-1 ( 400 % ), and PAI-1 ( > 20-fold ),
activation of
NFkappaB , and interstitial infiltrations of T cells and macrophages in the remnant kidneys
Gao et al., Am J Hypertens 2007
(Inflammation) :
These results indicate that
MCP-1 expression in inflammatory vascular injury is
regulated by activation of
NF-kappaB
Guo et al., Free Radic Biol Med 2008
:
CH3-Avn-c, a synthetically prepared methyl ester derivative of Avn-c with a high biological potency, significantly and dose dependently decreased mRNA expression and secretion of IL-6, IL-8, and
MCP-1 by HAEC as determined by real-time RT-PCR and ELISA, and it
inhibited IL-1beta- and TNFalpha stimulated
NF-kappaB activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay
Horiuchi et al., Drugs 2006
:
Nifedipine
inhibited MCP-1 expression by inhibiting
nuclear factor (NF)-kappaB activation
Fantuzzi et al., Blood 2008
(HIV Infections) :
Furthermore, PC-PLC is required for
NF-kB mediated
CCL2 production triggered by R5 gp120
Yin et al., Pediatr Transplant 2008
(Vascular Diseases) :
Both LFO and HFO significantly decreased the CAV score, inhibited recruitment of T lymphocytes and macrophages, elevated the activity of PPAR gamma,
inhibited the activity of
NF-kappaB , reduced levels of intragraft
MCP-1 and IP-10 as well as downregulated expression of chemokine receptors CCR2
Röder-Stolinski et al., Inhal Toxicol 2008
:
In the
presence of IKK-NBD, a specific
NF-kappa B inhibitor, or the inhibitors of the p38 MAP kinase SB 203580 and SB 202190, the chlorobenzene related
MCP-1 release was suppressed, suggesting an involvement of both pathways in the chlorobenzene induced expression of MCP-1
Lu et al., Cell Mol Neurobiol 2009
:
In order to determine the possible effects of hemolysate on brain microvascular endothelial cells ( BMECs ), we examined the effects of hemolysate on the expression of intercellular adhesion molecule-1 ( ICAM-1 ) and
monocyte chemoattractant protein-1 ( MCP-1 ), generation of reactive oxygen species ( ROS ), and
NF-kappaB activation in rat BMECs
Okamura et al., American journal of physiology. Renal physiology 2008
:
Subsequent experiments revealed that acute ablation of GRP78 protein by AB5 subtilase cytotoxin caused reinforcement of
MCP-1 induction and
NF-kappaB activation by TNF-alpha and that transfection with GRP78 significantly suppressed the cytokine induced activation of NF-kappaB
Kim et al., Mol Cells 2008
:
In addition, rosmarinic acid reduced cell migration by inducing the expression of a specific chemokine receptor on LPS induced mature BMDCs. Rosmarinic acid also significantly reduced the expressions of
MCP-1 and MIP-lalpha induced by LPS in BMDCs and
inhibited LPS induced activation of MAPK and the nuclear translocation of
NF-kappaB
El-Osta et al., J Exp Med 2008
(Diabetes Complications...) :
Both the epigenetic changes and the gene expression changes persist for at least 6 d of subsequent normal glycemia, as do
NF-kappaB induced increases in
monocyte chemoattractant protein 1 and vascular cell adhesion molecule 1 expression
Yubero et al., Biochim Biophys Acta 2009
(Pancreatitis) :
Pancreatic glutathione depletion, acinar overexpression of
monocyte chemoattractant protein-1 ( MCP-1 ) and cytokine induced neutrophil chemoattractant ( CINC ), and
activation of p38MAPK,
NF-kappaB and STAT3 were found in both AP models
El-Hage et al., PloS one 2008
:
Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine induced release of
MCP-1 , IL-6 and TNF-alpha by astrocytes is
NF-kappaB dependent
Yao et al., J Neurosci 2009
:
Blocking TRPC channels and specific downregulation of TRPC channels 1 and 5 resulted in suppression of
CCL2 induced ERK/CREB activation but not
Akt/NF-kappaB activation
Kannan et al., PloS one 2009
(Pseudomonas Infections) :
Mechanistically, we found that Lyn mediated
NFkappaB activation
led to increased gene expression and secretion of
MCP-1
Sutcliffe et al., Br J Pharmacol 2009
:
Transcriptional regulation of
monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells
involves NF-kappaB and AP-1
Pan et al., Braz J Med Biol Res 2009
(Inflammation) :
These data suggest that the inhibition of NAD ( P ) H oxidase dependent
NF-kappaB signaling
reduces the increase in
MCP-1 production by GECs induced by Ang II
Du et al., J Immunol 2009
:
In TNF-alpha treated cells, suppression of MCP-1 by CsA or FK506 was associated with blunted responses of
NF-kappaB , the crucial
regulator of
MCP-1
Lim et al., Food Chem Toxicol 2010
:
Curcumin
inhibits phorbol myristate acetate ( PMA ) -induced
MCP-1 expression by inhibiting ERK and
NF-kappaB transcriptional activity
Kim et al., American journal of physiology. Renal physiology 2010
(Disease Models, Animal...) :
In confirmation of earlier studies, rats with chronic renal failure exhibited increased lipid peroxidation, glutathione depletion,
NF-kappaB activation , mononuclear cell infiltration, and upregulation of
monocyte chemoattractant protein-1 , NAD ( P ) H oxidase, cyclooxygenase-2, and 12-lipoxygenase in the remnant kidney pointing to oxidative stress and inflammation
Giraud et al., Proc Natl Acad Sci U S A 2010
(Encephalomyelitis, Autoimmune, Experimental) :
Estradiol inhibits ongoing autoimmune neuroinflammation and
NFkappaB dependent
CCL2 expression in reactive astrocytes
Shimada et al., FEBS Lett 2010
:
In summary,
MCP-1 production was partly regulated by ROCK acting upstream of p38 and JNK and
mediated downstream by
NF-kappaB
Jiang et al., J Mol Endocrinol 2010
:
LPS significantly enhances
MCP-1 production and this is
dependent on
nuclear factor kappa B (NFkappaB) signaling, since the use of NFkappaB inhibitor pyrrolidine dithiocarbamate or the silencing of NFkappaB subunit p65 expression with specific siRNA largely impairs LPS enhanced MCP-1 production
Li et al., Am J Nephrol 2010
(Diabetes Mellitus, Experimental...) :
The expression of TLR2 mRNA and protein level was significantly upregulated in the kidneys of diabetic rats ( p < 0.01 ), which was associated with increased renal expression of MyD88 and
MCP-1 ,
activation of
NF-kappaB and infiltration of macrophages
Le Dréau et al., Glia 2010
:
Using a panel of kinase inhibitors, we demonstrated that NOV action on
CCL2 and CXCL1 production
involved a
Rho/ROCK/JNK/NF-kappaB and a Rho/qROCK/p38/NF-kappaB pathway, respectively
Spadaro et al., PloS one 2013
:
Notably, phosphatidylcholine-specific phospholipase C ( PC-PLC ), previously reported to be required for
NF-kB mediated
CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC ß1 nuclear localization induced by gp120
Ueda et al., J Immunol 1994
:
NF-kappa B and Sp1
regulate transcription of the human
monocyte chemoattractant protein-1 gene
Rovin et al., Kidney Int 1995
:
This study investigated the
role of
NF-kappa B in IL-1 induced
MCP-1 expression by human mesangial cells ... These data suggest that
MCP-1 gene transcription may be
mediated , in part, by the transcription factor
NF-kappa B
Freter et al., J Biol Chem 1996
:
Platelet derived growth factor induction of the immediate-early gene
MCP-1 is
mediated by
NF-kappaB and a 90-kDa phosphoprotein coactivator
Sato et al., J Rheumatol 1996
(Arthritis, Rheumatoid) :
Our data suggest that TNF-alpha
induces expression of proinflammatory cytokines such as IL-8 and
MCP-1 through generation of reactive oxygen intermediates and subsequent activation of
NF-kappa B in human synovial cells, and the antioxidants may inhibit, at least in part, the activation of NF-kappa B by TNF-alpha
Marumo et al., Circulation 1997
:
This PDGF induced O2.- production may be involved in vascular lesion formation by mediating, at least in part,
NF-kappaB activation and
MCP-1 induction
Kelly et al., Biochem Biophys Res Commun 1997
(Breast Neoplasms) :
MCP-1 synthesis is
stimulated by the transcription factor
NF-kappa B and is inhibited by glucocorticoid but the relevance of progesterone control in reproductive tissue is unknown
Ruiz-Ortega et al., J Immunol 1998
(Glomerulonephritis...) :
Since
NF-kappaB is
involved in the regulation of
MCP-1 gene, we explored whether the effects of AngII were mediated through NF-kappaB activation