◀ Back to NFKB1
BCL2 — NFKB1
Pathways - manually collected, often from reviews:
-
KEGG Apoptosis:
NFKB1/RELA
→
BCL2
(gene expression, expression)
-
KEGG Pathways in cancer:
NFKB1/NFKB2/RELA
→
BCL2
(gene expression, expression)
-
KEGG Prostate cancer:
NFKB1/RELA
→
BCL2
(gene expression, expression)
Text-mined interactions from Literome
Badrichani et al., J Clin Invest 1999
:
In addition, Bcl-2 or
Bcl-XL inhibits activation of
NF-kappaB and thus upregulation of proinflammatory genes ...
Bcl-2 mediated inhibition of
NF-kappaB in EC occurs upstream of IkappaBalpha degradation without affecting p65 mediated transactivation
Tamatani et al., J Biol Chem 1999
:
Tumor necrosis factor
induces Bcl-2 and Bcl-x expression through
NFkappaB activation in primary hippocampal neurons ... Expression of the mutant NFkappaB completely inhibited
NFkappaB DNA binding activity and
inhibited both TNF induced up-regulation of
Bcl-2 and Bcl-x expression and neuroprotective effect
Maulik et al., Ann N Y Acad Sci 1999
(Myocardial Ischemia...) :
In concert, the adapted myocardium is associated with increased antioxidant gene
Bcl-2 ,
increased binding activity of the nuclear transcription factor
NF kappa B , and reduced binding activity of AP-1 compared to nonadapted hearts
Zheng et al., J Immunol 2000
:
Transduced
Bcl-2 did not
reduce TNF mediated
NF-kappaB activation or constitutive expression of class I MHC molecules
Tamatani et al., J Neurochem 2000
:
These findings suggest a pathway where
NFkappaB activation
induces overexpression of
Bcl-2 and Bcl-x, which function to prevent apoptotic cell death following H/R treatments
Bertin et al., J Biol Chem 2000
:
Although its role in apoptosis remains to be determined,
BCL10 likely
activates NF-kappaB through the IKK complex in response to upstream stimuli
Kirshenbaum et al., Clin Invest Med 2000
:
Moreover, the
Bcl-2 mediated
NFkappaB activation was found to be related to changes in the activity of the NFkappaB regulatory protein IkappaBalpha ( inhibitor of kappa beta )
Sasaki et al., Antioxid Redox Signal 1999
(Myocardial Ischemia...) :
Ischemic adaptation attenuates apoptotic cell death, further increases
NF-kappaB binding activity and
Bcl-2 gene
induction , but reduces AP-1 binding activity
Kanai et al., Gastroenterology 2001
:
TGF-alpha also enhanced the expression of
Bcl-2 family proteins in an
NF-kappaB dependent manner
Kurland et al., J Biol Chem 2001
:
We investigated the
role of
NF-kappaB1 ( p50 ) homodimers in the expression of
Bcl-2 in two murine B-cell lymphoma cell lines : LY-as, an apoptosis-proficient line with low Bcl-2 protein expression and no nuclear NF-kappaB activity, and LY-ar, a nonapoptotic line with constitutive p50 homodimer activity and 30 times more Bcl-2 protein expression than LY-as
Heckman et al., Oncogene 2002
(Lymphoma...) :
NF-kappaB activates
Bcl-2 expression in t ( 14 ; 18 ) lymphoma cells ... Conflicting evidence exists on the
effects of
NF-kappaB expression on
Bcl-2 levels in different cell types
Regula et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
IKK beta is required for
Bcl-2 mediated
NF-kappa B activation in ventricular myocytes ... The underlying mechanism by which
Bcl-2 activates
NF-kappa B is undefined ... In view of growing evidence that the I kappa B kinases ( IKKs ), notably IKK beta, are involved in signal induced phosphorylation of I kappa B alpha, we ascertained whether IKK beta is necessary and sufficient for
Bcl-2 mediated
NF-kappa B activation ... Here we demonstrate that expression of
Bcl-2 in ventricular myocytes
resulted in an increase in NF-kappa B-dependent DNA binding,
NF-kappa B gene transcription and reduced I kappa B alpha levels ... Catalytically inactive mutants of IKK beta, but not IKK alpha, suppressed
Bcl-2 mediated I kappa B alpha phosphorylation and
NF-kappa B activation ... Transfection of human embryonic 293 cells with a kinase-defective Raf-1 or a kinase-defective mitogen activated protein kinase/extracellular signal regulated kinase kinase-1 ( MEKK-1 ) suppressed
Bcl-2 mediated IKK beta activity and
NF-kappa B activation ... Further,
Bcl-2 mediated
NF-kappa B activity was impaired in nullizygous mouse embryonic fibroblasts deficient for IKK beta
Chendil et al., Cancer Biol Ther 2002
(Prostatic Neoplasms) :
Exposure of PC-3 cells to Ad5-I kappa B super-repressor inhibited radiation induced Bcl-2 expression indicating that radiation induced
NF kappa B activity is
required for the induction of
Bcl-2 protein
Fujioka et al., Oncogene 2003
(Adenocarcinoma...) :
Inhibiting
NF-kappa B signaling by expressing I kappa B alpha M significantly
reduced expression of Bcl-x ( L ) and
Bcl-2
Zheng et al., J Exp Med 2003
:
Our results further indicate that
NF-kappaB regulates TCR induced expression of antiapoptotic
Bcl-2 family members
Kurland et al., J Biol Chem 2003
(Lymphoma, B-Cell) :
In a previously published report ( Kurland, J. F., Kodym, R., Story, M. D., Spurgers, K. B., McDonnell, T. J., and Meyn, R. E. ( 2001 ) J. Biol. Chem. 276, 45380-45386 ), we described the NF kappa B status for two murine B-cell lymphoma cell lines, LY-as ( apoptosis-sensitive ) and LY-ar ( apoptosis-refractory ) and provided evidence that
NF kappa B1 ( p50 ) homodimers
contribute to the expression of
Bcl-2 in the LY-ar line
Massaad et al., Neuroreport 2003
:
Bcl-2 phosphorylation is not
required for its effects on
NFkappaB activity ... To study whether effects on NFkappaB are part of the Bcl-2 anti-apoptotic mechanism, we examined the
effect of
Bcl-2 on
NFkappaB transcriptional activity in PC12 cells and determined the role thereby of Bcl-2 phosphorylation ( required for the anti-apoptotic function of Bcl-2 ) ... We conclude that such
Bcl-2 effect on
NFkappaB activity is distinct from its anti-apoptotic action
Viatour et al., Leukemia 2003
(Breast Neoplasms...) :
NF- kappa B2/p100 induces
Bcl-2 expression
Yorke et al., Eur J Cancer 2003
(Adenocarcinoma...) :
Receptor activator of
NF-kappaB ( RANK ) activation
induces several survival signals including nuclear factor kappaB (NF-kappaB) and activation and upregulation of
Bcl-xL
Misra et al., Circulation 2003
(Myocardial Infarction...) :
These studies suggest that the cytoprotective effects of
NF-kappaB are
mediated , at least in part, by
Bcl-2 or c-IAP1
Arnold et al., Neuroimmunomodulation 2004
(Lymphoma) :
Western blot analysis
detected an increase in
Bcl-2 while the levels of
nuclear factor kappa B (NFkappaB) remained unchanged in GHo cells
Song et al., Neurosci Res 2004
:
However, overexpression of
Bcl-2 reduced Abeta induced apoptosis, and
suppressed the activation of p38 MAP kinase and
NF-kappaB ... Moreover, inhibition of
NF-kappaB activation by sodium salicylates reduced Abeta induced apoptosis and activation of p38 MAP kinase, and up
regulated Bcl-2 expression
Shukla et al., Neoplasia (New York, N.Y.) 2004
(Adenocarcinoma...) :
The nuclear levels of NF-kappaB/p65 correlated with concurrent increase in cytosolic levels of IkappaBalpha along with
NF-kappaB dependent expression of
Bcl2 , cyclin D1, MMP-9, and VEGF
Chen et al., Apoptosis 2004
(Colonic Neoplasms) :
Bcl-2, and to the less extent,
Bcl-xL , were able to
increase the activity of
NF-kappa B , which was a known anti-apoptotic molecule in human colon cancer cells
Tran et al., J Biol Chem 2005
(Astrocytoma...) :
In addition, Fn14 activation induced
BCL-XL and BCL-W mRNA and protein levels, and this effect was
dependent upon
NFkappaB transcriptional activity ... Our results suggest that
NFkappaB mediated up-regulation of BCL-XL and
BCL-W expression in glioma cells increases cellular resistance to cytotoxic therapy induced apoptosis
Akita et al., Virology 2005
:
p21WAF1 modulates
NF-kappaB signaling and
induces anti-apoptotic protein
Bcl-2 in Tax expressing rat fibroblast
Pozo-Guisado et al., Int J Cancer 2005
:
NF-kappaB , a
regulator of
Bcl-2 expression, and calpain protease activity, a regulator of NF-kappaB, were both inhibited by RES
Fahy et al., Cancer Chemother Pharmacol 2005
(Breast Neoplasms...) :
The effect of mutation of a NF-kappaB site in the BCL-2 promoter was determined, as was the
effect of inhibition of
NF-kappaB function using a 26S proteasome inhibitor ( bortezomib ) on both
BCL-2 transcription and induction of apoptosis
Tracey et al., J Pathol 2005
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
Meanwhile, in chronic lymphocytic leukaemia ( CLL ) -derived lymphocytes,
NF-kappaB inhibition
resulted in a marked decrease in
BCL2 expression
Hu et al., J Clin Invest 2006
(Lymphoma, B-Cell, Marginal Zone...) :
Furthermore,
BCL10 and cIAP2-MALT1 synergistically
activate NF-kappaB
Tao et al., Mol Cell Biol 2006
:
Up-regulation of proapoptotic protein
Bcl-XS and neuronal apoptosis induced by serum deprivation are
blocked by inhibition and/or down-regulation of
NF-kappaB and by prevention of K+ loss
Choi et al., Experimental biology and medicine (Maywood, N.J.) 2006
(Hyperoxia...) :
These results indicate that hyperoxia induces myocardial tolerance against ischemia-reperfusion injury in association with
Bcl-2 induction by
NF-kappaB activation through reactive oxygen species and PKC dependent signaling pathway
Kooncumchoo et al., J Mol Neurosci 2006
(Parkinson Disease) :
In this study we have determined the neuroprotective role of coenzyme Q ( 10 ) ( CoQ ( 10 ) ) in ironinduced apoptosis in cultured human dopaminergic ( SK-N-SH ) neurons, in metallothionein gene- manipulated mice, and in alpha-synuclein knockout ( alpha-synko ) mice with a primary objective to assess a possible therapeutic and anti-inflammatory potential for CoQ ( 10 ) in PD. Iron induced mitochondrial damage and apoptosis were characterized by reactive oxygen species production, increased metallothionein and glutathione synthesis, caspase- 3 activation,
NF-kappaB induction , and decreased
Bcl-2 expression, without any significant change in Bax expression
Khanbolooki et al., Mol Cancer Ther 2006
(Pancreatic Neoplasms) :
NF-kappaB inhibition
resulted in down-regulation of
BCL-XL and XIAP, and silencing either restored TRAIL sensitivity in TRAIL-resistant cells
Karmakar et al., Apoptosis 2007
(Neuroblastoma) :
Apoptosis was associated with an increase in [ Ca ( 2+ ) ] ( i ), increase in Bax :
Bcl-2 ratio, mitochondrial release of cytochrome c, increase in cytosolic Smac/Diablo, and down
regulation of inhibitor-of-apoptosis proteins and
nuclear factor kappa B (NFkappaB)
Deeb et al., J Pharmacol Exp Ther 2007
(Prostatic Neoplasms) :
Because expression of antiapoptotic Bcl-2,
Bcl-xL , and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is
regulated by
NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB ... Because expression of antiapoptotic
Bcl-2 , Bcl-xL, and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) is
regulated by
NF-kappaB , both curcumin and SH-6 decreased the levels of these proteins in PC3 cells through inhibition of NF-kappaB
Kunnumakkara et al., Cancer Res 2007
(Neovascularization, Pathologic...) :
In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ),
NF-kappaB activation , and expression of NF-kappaB regulated gene products ( cyclin D1, c-myc, Bcl-2,
Bcl-xL , cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only ... In vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume ( P = 0.008 versus control ; P = 0.036 versus gemcitabine alone ), Ki-67 proliferation index ( P = 0.030 versus control ), NF-kappaB activation, and expression of
NF-kappaB regulated gene products ( cyclin D1, c-myc,
Bcl-2 , Bcl-xL, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor ) compared with tumors from control mice treated with olive oil only
Takase et al., Kidney Int 2008
(Chronic Disease...) :
Inhibition of
NF-kappaB dependent
Bcl-xL expression by clusterin promotes albumin induced tubular cell apoptosis
Lee et al., Int J Cancer 2008
(Carcinoma, Squamous Cell...) :
A signal network
involving coactivated
NF-kappaB and STAT3 and altered p53 modulates
BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas
Aimbire et al., Int Immunopharmacol 2008
(Inflammation) :
LLLT and an inhibitor of
NF-kappaB nuclear translocation ( BMS 205820 )
attenuated the mRNA levels of
Bcl-xL and A1 mRNA in lung neutrophils obtained from mice subjected to LPS induced inflammation
Iyer et al., Cell Microbiol 2008
(Leukemia, Myeloid) :
L. reuteri downregulated
nuclear factor-kappaB (NF-kappaB) dependent gene products that mediate cell proliferation ( Cox-2, cyclin D1 ) and cell survival (
Bcl-2 , Bcl-xL )
Ghosh-Choudhury et al., Breast Cancer Res Treat 2009
(Adenocarcinoma...) :
NFkappaB DNA binding activity and
NFkappaB dependent transcription of Bcl-2 and
Bcl-XL genes were also prevented by DHA and EPA treatment ... NFkappaB DNA binding activity and
NFkappaB dependent transcription of
Bcl-2 and Bcl-XL genes were also prevented by DHA and EPA treatment ... Finally, we showed that PTEN expression significantly inhibited
NFkappaB dependent transcription of Bcl-2 and
Bcl-XL genes ... Finally, we showed that PTEN expression significantly inhibited
NFkappaB dependent transcription of
Bcl-2 and Bcl-XL genes
Marrero et al., Brain Res 2009
(Inflammation) :
In this study, we investigated the effects of inhibiting the alpha7 nAChR-JAK2 pro-survival cascade on the nicotine induced production of the survival factor
Bcl-2 and the transcriptional
activation of
NF-kappaB , AP-1, STAT1, STAT3, and STAT5
Kim et al., Arch Pharm Res 2009
(Colonic Neoplasms) :
NF-kappaB target gene expression of apoptotic cell death proteins ( Bax, caspase-3, caspase-9 ) was significantly enhanced, but the expression of anti-apoptotic genes and cell proliferation marker genes (
Bcl-2 , inhibitor of apoptosis protein ( IAP-1 ) and X chromosome IAP (XIAP), Cox-2, c-Fos, c-Jun and cyclin D1 ) was significantly
inhibited by the combined treatment compared to Rg3 or docetaxel alone
Banerjee et al., Cancer Res 2009
(Pancreatic Neoplasms) :
Our data provide mechanistic evidence for the first time showing that DIM potentiates the killing of pancreatic cancer cells by down-regulation of constitutive as well as drug induced
activation of
NF-kappaB and its downstream genes (
Bcl-xL , XIAP, cIAP, and survivin )
Nehra et al., FASEB J 2010
(Breast Neoplasms) :
NF-kappaB inhibition
restores the ability of 4HT to decrease
BCL2 expression, increase mitochondrial membrane permeability, and induce a caspase dependent apoptotic cell death in resistant cells
Liu et al., J Biol Chem 2010
:
Overall, our results suggest that AMPKalpha1, but not AMPKalpha2 activation, promotes cell survival by increasing
NF-kappaB mediated expression of anti-apoptotic proteins (
Bcl-2 and Survivin ) and intracellular ATP contents
Priyadarsini et al., Free radical research 2010
:
Altered expression of the
Bcl-2 family of proteins,
inhibition of
NF-kappaB activation and over-expression of caspases and survivin provide compelling evidence that azadirachtin and nimbolide induce a shift of balance toward a pro-apoptotic phenotype
Huang et al., Biomaterials 2010
(Melanoma) :
Further results demonstrated that the upregulation of anti-apoptotic molecules
Bcl-2 expression and the
inhibition of
NF-kappaB activation by MSNs may promote cell proliferation in a redox-sensitive signal pathway
Wang et al., Microb Pathog 2010
:
Because expressions of anti-apoptotic
Bcl-2 , survivin, inhibition of apoptosis protein ( cIAP ), and X-chromosome linked inhibitor of apoptosis protein ( XIAP ) are
regulated by
NF-kappaB , S. aureus decreased the levels of these proteins in U937 cells through inhibition of NF-kappaB
Coscia et al., Leukemia 2011
(Leukemia, Lymphocytic, Chronic, B-Cell) :
Nuclear factor-kB (NF-kB) was rapidly inactivated, and
B-cell leukemia/lymphoma 2 (Bcl-2) expression progressively
down-regulated in the UM CLL B cells
Wang et al., J Chemother 2012
(Breast Neoplasms) :
Our results showed that TNF-alpha treatment increased Bcl-2 mRNA and protein levels in breast cancer cells, suggesting that
Bcl-2 is directly
regulated by
nuclear factor-kappaB (NF-kappaB) in response to TNF-alpha
Zhang et al., Mol Cell Biol 1994
(Leukemia, Lymphocytic, Chronic, B-Cell...) :
In contrast to I kappa B alpha ( MAD3 ),
BCL3 does not
cause NF-kappa B p50 to be retained in the cytoplasm ; instead, in cotransfection assays, it alters the subnuclear localization of p50
Lin et al., J Cell Biol 1995
(Neuroblastoma...) :
Understanding the precise mechanism by which
Bcl-2 and thiol agents
inhibit SV-induced nuclear
NF-kappa B activity in AT-3 cells may provide insights into the pluripotent antiapoptotic actions of these agents
Grimm et al., J Cell Biol 1996
:
Bcl-2 inhibited
NF-kappaB activity by an unusual mechanism
de Moissac et al., J Biol Chem 1998
:
Bcl-2 activates the transcription factor
NFkappaB through the degradation of the cytoplasmic inhibitor IkappaBalpha