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CSF3 — TYK2

Text-mined interactions from Literome

Novak et al., Growth Factors 1996 : Instead of increased phosphorylation of JAK1 and JAK2 in response to G-CSF and interferon-gamma, and JAK1 and Tyk2 in response to interferon-alpha/beta, we observed only an increase of phosphorylation of Tyk2 in response to all of these cytokines in NFS-60 cells
Avalos et al., Exp Hematol 1997 : In murine Ba/F3 cells transfected with the human G-CSFR and NFS-60 cells constitutively expressing the murine G-CSFR, G-CSF induced tyrosine phosphorylation and activation of Jak1, Jak2, and Tyk2
Shimoda et al., Blood 1997 (Fibrosarcoma) : In both myeloid cells and a human fibrosarcoma cell line expressing the G-CSF receptor, G-CSF induces the tyrosine phosphorylation and activation of Jak1, Jak2, and Tyk2 ... In the absence of Jak1, G-CSF induces activation of Jak2 and Tyk2 , but fails to induce receptor tyrosine phosphorylation and induces dramatically reduced levels of Stat activation