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IL6 — PAM

Text-mined interactions from Literome

Kumar et al., Microbes Infect 2006 : The treatment of HUCL cells with TLR2 neutralizing antibody resulted in a significant decrease in Pam3Cys induced hBD2 production as well as IL-6 , IL-8, and TNF-alpha secretion
Frost et al., Am J Physiol Regul Integr Comp Physiol 2006 : LPS- and Pam stimulated IL-6 expression was inhibited by the proteasome inhibitor MG-132 and the IkappaB kinase-2 (IKK2) inhibitor 2- [ ( aminocarbonyl ) amino ] -5- ( 4-fluorophenyl ) -3-thiophenecarboxamide ( TPCA-1 ) ... Pam stimulated NF-kappaB and IL-6 promoter activities were disrupted by a dominant negative form of TLR2, but not TLR4
Davey et al., Microvasc Res 2006 : Endothelial cells from choroid demonstrated enhanced release of IL-6 in response to MDP, and synergy was observed following treatment with MDP and either Pam3CSK4 or LPS
Soboll et al., Biol Reprod 2006 : When added to the apical surface for 48 h before analysis, the TLR2-agonist Pam3Cys-Ser- ( Lys ) 4 and TLR1/6-agonist peptidoglycan increased epithelial cell apical secretion of IL1A, CCL2, and IL6 and apical/basolateral bidirectional secretion of CSF2, TNFA, CSF3, and IL8 when compared to controls
Kopp et al., Obesity (Silver Spring) 2009 : The effects of lipopolysaccharide (LPS), flagellin, Poly ( U ), Poly ( I:C ), macrophage activating lipopeptide-2 ( MALP2 ), Pam3Cys , and CpG on the release of interleukin-6 (IL-6) , resistin, and monocyte chemoattractant protein-1 ( MCP-1 ) were determined by enzyme linked immunosorbent assay ( ELISA )
Juarez et al., Respir Res 2010 (Tuberculosis) : Corresponding with the reduced surface and mRNA expression of TLR2, Pam3Cys induced lower production of TNF-alpha, IL-1beta and IL-6 in bronchoalveolar cells than in monocytes
Horton et al., Clinical and vaccine immunology : CVI 2010 (Inflammation) : PAM stimulation also induced IL-1beta, IL-6 , and IL-8 ... In contrast, delayed DEX addition significantly suppressed PAM induced IL-1beta, IL-6 , or IL-8 and also suppressed LPS induced IL-1beta and IL-8
Park et al., J Oral Pathol Med 2010 (Carcinoma, Squamous Cell...) : IL-6 and IL-8 production was increased by Pam ( 3 ) CSK ( 4 ), flagellin, Poly I:C, and imiquimod, but not lipopolysaccharide (LPS)
Chen et al., Dig Dis Sci 2011 (Salmonella Infections) : IAP-KO whole-blood stimulation with LPS and Pam-3-Cys resulted in increased IL-6 and tumor necrosis factor (TNF)-alpha secretion compared with WT
Ultaigh et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid) : OPN301 significantly decreased Pam3CSK4 induced cytokine production of tumour necrosis factor alpha ( TNF-a ), IL-1ß, IL-6 , interferon ( IFN ) -? and IL-8 compared to IgG control in RA PBMCs and SFMCs cultures ( all P < 0.05 )
Caraş et al., Roum Arch Microbiol Immunol 2011 : Unexpectedly, treatment with anti-LR2 blocking antibody inhibited only IL-6 production induced by Pam3CSK4 while the level of TNF-alpha was unchanged
Jin et al., Biosci Biotechnol Biochem 2011 : IL-6 secretion in the J774.1 cells was markedly increased by Pam3CS4 , LPS, and CpG, the ligands to TLR1/2, 4, and 9 respectively
Funderburg et al., Immunology 2011 : Monocytes incubated with hBD-3 or Pam ( 3 ) CSK ( 4 ) produced interleukin-6 (IL-6) , IL-8 and IL-1ß, but only Pam ( 3 ) CSK ( 4 ) induced IL-10
Li et al., Inflammation 2012 (Endotoxemia) : We found that in vitro LPS and Pam3CSK4 induced TNF-a, and IL-6 production are decreased in macrophages from GS/GS mice compared with WT mice ( p? < ?0.05 )
Morandini et al., J Periodontol 2013 (Inflammation) : Knockdown of TLR2 decreased IL-6 and IL-8 in response to P. gingivalis LPS, or Pam2CSK4 and Pam3CSK4, in a similar manner in both fibroblasts subpopulations
Tan et al., Mol Pharm 2012 (Inflammation...) : In this study, we demonstrate that the Toll-like receptor-2 agonist Pam2Cys , when administered intranasally, triggers a cascade of inflammatory and innate immune signals, acting as an immunostimulant by attracting neutrophils and macrophages and inducing secretion of IL-2, IL-6 , IL-10, IFN-?, MCP-1 and TNF-a
Lee et al., Arterioscler Thromb Vasc Biol 2012 (Atherosclerosis) : Moreover, cAMP response element binding protein small interfering RNA inhibited pam3CSK4 induced IL-6 production and VSMC migration ... Additionally, Rac1 small interfering RNA inhibited pam3CSK4 induced VSMC migration but not IL-6 production
Soberman et al., PloS one 2012 (Encephalitis...) : CD200R1 ( -/- ) peritoneal macrophages demonstrated a 70-75 % decrease in the generation of IL-6 and CCL5 ( Rantes ) in response to the TLR2 agonist Pam ( 2 ) CSK ( 4 ) and to HSV-1
Beenakker et al., Aging Cell 2013 : Upon stimulation with Pam3Cys-SK4 , IL-6 ; TNF-a ; and Il-1ß were significantly positively associated with lean body mass and appendicular lean in women, but not in men