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GPI — IL2
Text-mined interactions from Literome
Matkó et al., Eur J Biochem 2002
(Leukemia, T-Cell...) :
Rafts may promote rapid formation of a high affinity IL-2R complex, even at low levels of IL-2 stimulus, and may also form a platform for the regulation of
IL-2 induced signals by
GPI-proteins ( e.g. CD48 )
Chen et al., J Interferon Res 1992
:
We investigated the augmenting effect of mouse recombinant interferon-beta ( MurIFN-beta ) on the
induction of macrophage ( M
phi ) cytolytic activity by
interleukin-2 (IL-2) ... MurIFN-beta showed a dose dependent enhancement on the
induction of anti-M
phi activity by
IL-2 with a peak at 2,000-10,000 U/ml, and the augmenting effect of rIFN-beta was more marked on lower doses of rIL-2 than on higher doses ... This augmenting effect was also observed in IFN-alpha, whereas IFN-gamma showed no influence on
IL-2 induced anti-M
phi activity
Yoshimura et al., Transplantation 1991
:
To dissect the immunosuppressive activity of AMF, the
effect of
AMF on cytokine production and
interleukin 2 (IL-2) receptor expression of concanavalin A-stimulated lymphocytes were investigated ...
AMF suppressed interferon and
IL-2 production ... Interestingly, however,
AMF did not
suppress interleukin 3 (IL-3) and interleukin 6 (IL-6) production, as well as
IL-2 receptor expression
Klarnet et al., J Immunol 1989
:
Stimulation with FBL alone in the absence of M phi or IL-1 was sufficient for induction of IL-2R expression, and rendered cells responsive to IL-2, but M
phi or IL-1 were also
required to induce production of
IL-2
Mills et al., J Biol Chem 1985
:
In this study, we established that
IL 2 produces an
increase in
pHi and determined whether this increase in pHi plays a role in the proliferative response to IL 2 ... Monitoring pHi with an intracellularly trapped, pH-sensitive, fluorescent dye, 2',7'-bis ( carboxyethyl ) -5,6-carboxyfluorescein, we demonstrated that
IL 2 rapidly ( less than 90 s )
initiates an increase in
pHi in IL 2-sensitive human and murine T cells
Frasier-Scott et al., J Clin Invest 1988
:
Both purified natural
IL-2 ( nIL-2 ) and rIL-2
induced significant
PGI2 synthesis ... We conclude that
IL-2 stimulated sustained
PGI2 production by a mechanism that includes the de novo synthesis of PGH synthase
Sasaki et al., Blood 1997
(Hematologic Neoplasms...) :
Phorbol 12-myristate 13-acetate ( PMA ),
interleukin-1 (IL-1), IL-3, IL-6, granulocyte-macrophage colony stimulating factor ( GM-CSF ), thrombopoietin (TPO), and tumor necrosis factor-alpha (TNF-alpha)
enhanced PGI2-R mRNA expression