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CCR6 — HNRNPH1
Text-mined interactions from Literome
Sato et al., J Immunol 2000
:
Stimulation of mature
DCs with TGF-beta 1 also
enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5,
CCR-6 , and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Le Borgne et al., Immunity 2006
:
Recruitment of circulating DC precursors, including Gr1+ monocytes, precedes the sequential accumulation of CD11c+ MHC class II+
DCs in dermis and epithelium via a
CCR6/CCL20 dependent mechanism
Salazar-Gonzalez et al., Immunity 2006
(Salmonella Infections) :
Thus,
CCR6 dependent regulation of
DCs is responsible for localized T cell dependent defense against entero-invasive pathogens ... Thus,
CCR6 dependent regulation of
DCs is responsible for localized T cell dependent defense against entero-invasive pathogens
Phadke et al., Am J Respir Crit Care Med 2007
(Aspergillosis, Allergic Bronchopulmonary...) :
In adoptive transfer experiments, however,
DCs from CCR6-deficient donors showed lesser accumulation in the lungs of infected mice as compared with wild-type cells, and transfer of wild-type, but not
CCR6-deficient , DCs
resulted in attenuated severity of infection in CCR6-deficient recipients
Robays et al., J Immunol 2007
(Asthma) :
Using this approach, we show that CCR2, but not CCR5 or
CCR6 , directly
controls the accumulation of
DCs into allergic lungs
Dieu et al., J Exp Med 1998
:
Finally, detection by in situ hybridization of MIP-3alpha mRNA only within inflamed epithelial crypts of tonsils, and of MIP-3beta mRNA specifically in T cell-rich areas, suggests a
role for
MIP-3alpha/CCR6 in recruitment of immature DCs at site of injury and for MIP-3beta/CCR7 in accumulation of antigen loaded mature
DCs in T cell-rich areas