◀ Back to PAK1
PAK1 — PAK3
Pathways - manually collected, often from reviews:
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BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN)
(modification, collaborate)
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BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
-
BioCarta agrin in postsynaptic differentiation:
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1)
→
agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3)
(modification, collaborate)
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NCI Pathway Database Regulation of p38-alpha and p38-beta:
RAC1-CDC42/GTP/PAK family complex (RAC1_CDC42-PAK2_PAK3_PAK1)
→
PAK family (PAK2/PAK3/PAK1)
(modification, collaborate)
Bagrodia et al., J Biol Chem 1995, Zhang et al., J Biol Chem 1995, Martin et al., EMBO J 1995, Manser et al., Nature 1994
Evidence: mutant phenotype, assay, physical interaction, other species
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NCI Pathway Database Regulation of p38-alpha and p38-beta:
RAC1-CDC42/GTP/PAK family complex (RAC1_CDC42-PAK2_PAK3_PAK1)
→
PAK family (PAK2/PAK3/PAK1)
(modification, collaborate)
Bagrodia et al., J Biol Chem 1995, Zhang et al., J Biol Chem 1995, Martin et al., EMBO J 1995, Manser et al., Nature 1994
Evidence: mutant phenotype, assay, physical interaction, other species
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Reactome Reaction:
PAK1
→
PAK3
(reaction)
Gatti et al., J Biol Chem 1999, Daniels et al., Trends Biochem Sci 1999, Chong et al., J Biol Chem 2001, Whitford et al., Neuron 2001, Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005, Szczepanowska et al., Acta biochimica Polonica 2009
Text-mined interactions from Literome
Volinsky et al., Biochem J 2006
:
Pak(i) potently
inhibited SDF-1alpha induced
Pak activation by a bivalent mechanism, as indicated by its complete inactivation upon point mutation of two binding sites, but partial inactivation upon mutation of either site alone
Nukada et al., Int Immunol 2006
:
PAK3 is
induced by the activation of T cells, whereas
PAK1 is constitutively expressed in both naive and activated T cells
Combeau et al., J Biol Chem 2012
(Genetic Diseases, X-Linked...) :
Using kinase assays, we demonstrate that
PAK1 inhibits the activity of
PAK3a but not of the splice variant PAK3b in a trans-regulatory manner
Rouquette-Jazdanian et al., Mol Cell 2012
(MAP Kinase Signaling System) :
The PLC-?1 ( SH3 )
-Pak1 interaction
activates Pak1 independently of the small GTPases Rac1/Cdc42, previously described as being the only activators of Pak1 in T cells
Bokoch et al., J Biol Chem 1998
:
Lipid stimulation of
PAK1 activity was
dependent upon intact
PAK kinase activity, as indicated by studies with a kinase-dead PAK1 mutant