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P2RY12 — PARP1
Text-mined interactions from Literome
Lova et al., J Biol Chem 2003
(Second Messenger Systems) :
Two unrelated inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002, totally prevented
Rap1B activation in platelets stimulated by cross linking of FcgammaRIIA, by stimulation of the
P2Y(12) receptor for ADP, or by epinephrine
Danielewski et al., Thromb Haemost 2005
(Calcium Signaling) :
Furthermore, cGKI inhibited ADP induced
Rap 1 activation
induced by the Galpha ( i ) -coupled
P2Y12 receptor alone, i.e. independently of effects on Ca2+ signalling
Holinstat et al., J Biol Chem 2006
(Calcium Signaling) :
Furthermore, we show that
P2Y12 receptor activation is not required for protease activated receptor mediated aggregation at higher agonist concentrations and is only partially
required for
Rap1 as well as GPIIbIIIa activation
Stefanini et al., Arterioscler Thromb Vasc Biol 2012
:
Whereas Rap1 signaling directly controls sustained Rac1 activation, Rac1 affects CalDAG-GEFI- and
P2Y12 dependent
Rap1 activation via its role in calcium mobilization and granule/ADP release, respectively