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TLR4 — TREM1

Pathways - manually collected, often from reviews:

• WikiPathways Regulation of toll-like receptor signaling pathway: TREM1 → TLR4 (unknown)

Text-mined interactions from Literome

Bleharski et al., J Immunol 2003 (Inflammation) : Expression of TREM-1 was up-regulated in response to TLR activation, an effect further enhanced by GM-CSF and TNF-alpha but inhibited by IL-10
Fortin et al., Int Immunol 2007 : Moreover, we observed that Toll-like receptor 4 and TREM-1 co-localize upon stimulation and TREM-1 engagement resulted in the phosphorylation of IL-1R associated kinase 1, but not its stimulant induced degradation
Watarai et al., Proc Natl Acad Sci U S A 2008 : Thus, PDC-TREM is responsible for IFN-alpha production, whereas TLR signals are essential for PDC-TREM expression