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CDKN1A — PAK2
Text-mined interactions from Literome
Roig et al., J Biol Chem 1999
:
p21 activated protein kinase
gamma-PAK is activated by ionizing radiation and other DNA damaging agents
Roig et al., J Biol Chem 2000
:
p21 activated protein kinase
gamma-PAK is translocated and activated in response to hyperosmolarity
Jakobi et al., Eur J Biochem 2000
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Substrates enhance autophosphorylation and activation of
p21 activated protein kinase
gamma-PAK in the absence of activation loop phosphorylation
Roig et al., Vitam Horm 2001
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Cytostatic
p21 G protein
activated protein kinase
gamma-PAK
Roig et al., FEBS Lett 2001
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Autophosphorylation of
p21 activated protein kinase
gamma-PAK is stimulated at 10 microM sphingosine in vitro and is maximal at 100 microM
Tuazon et al., FEBS Lett 2002
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p21 activated protein kinase
gamma-PAK phosphorylates prolactin (PRL) in rat pituitary secretory granules on Ser-177 and on the equivalent site, Ser-179, in recombinant human PRL
Brown et al., Mol Biol Cell 2002
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The precise temporal-spatial regulation of the
p21 activated serine-threonine kinase
PAK at the plasma membrane is required for proper cytoskeletal reorganization and cell motility
Huang et al., J Biol Chem 2003
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Localization of
p21 activated protein kinase
gamma-PAK/Pak2 in the endoplasmic reticulum is required for induction of cytostasis
Miah et al., Mol Cell Biol 2004
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Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with
p21 activated protein kinase
Pak2/gamma-PAK
Foster et al., J Neuroimmune Pharmacol 2011
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The poorly understood Nef functions of
p21 activated protein kinase (
PAK2 ) activation, enhancement of virion infectivity, and inhibition of immunoglobulin class switching are also likely to involve ternary complexes and non-canonical interactions
Meshki et al., PloS one 2011
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Although
p21 activated kinase (PAK) is expressed in both cell lines, SP
induced rapid phosphorylation of
PAK in U373MG, but failed to phosphorylate PAK in HEK293-NK1R cells
Walter et al., J Biol Chem 1998
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Cleavage and activation of
p21 activated protein kinase
gamma-PAK by CPP32 ( caspase 3 ) ...
p21 activated protein kinase
gamma-PAK ( Pak2, PAK I ) is cleaved by CPP32 ( caspase 3 ) during apoptosis and plays a key role in regulation of cell death
Tuazon et al., Biochemistry 1998
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Autophosphorylation and protein kinase activity of
p21 activated protein kinase
gamma-PAK are differentially affected by magnesium and manganese