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CDKN1A — HGF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → HGF (decreases)
  Evidence: SF blocked ADR-induced increases in c-Myc and inhibited the expression of p21WAF1/CIP1 and of the BRCA1 protein in MDA-MB-453 cells

Text-mined interactions from Literome

DiGiuseppe et al., In Vivo 1999 (Leukemia, Erythroblastic, Acute...) : In contrast, HGF enhanced basal and etoposide induced p21WAF1/CIP1 protein levels in 9/11 and 7/11 of the cases, respectively
Royal et al., Mol Biol Cell 2000 : HGF induces activation of the Cdc42/Rac regulated p21 activated kinase (PAK) and c-Jun N-terminal kinase, and translocation of Rac, PAK, and Rho dependent Rho-kinase to membrane ruffles
Yang et al., J Cell Physiol 2007 (Carcinoma, Hepatocellular...) : At HD, HGF increased the mRNA levels of p21 and p27, while lowering the levels of MAT genes, cyclin A, and c-met
Park et al., BMC nephrology 2007 (Polycystic Kidney, Autosomal Dominant) : In addition, hepatocyte growth factor , which induces transition from a cystic to a tubular phenotype, increases p21 levels
Chen et al., Bone 2011 : Transfection of siRNA specific for cMet, the HGF receptor, eliminated the HGF anti-proliferation effect on hMSCs and the HGF mediated increase in p53, p21 , and p27, strongly supporting a role for these cell-cycle inhibitors in HGF 's regulation of hMSCs
Iwabayashi et al., Biochem Biophys Res Commun 2012 (Atherosclerosis...) : On the other hand, HGF significantly attenuated EPC dysfunction, senescence, ROS production, and p53 and p21 expression induced by Lp(a)
Nishiyama et al., Mol Cell Biol 1994 : rac p21 is involved in insulin induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) -induced membrane ruffling in KB cells ... These results indicate that rac p21 and rho GDI are involved in insulin induced membrane ruffling and that rho p21 and rho GDI are involved in HGF- and phorbol ester induced membrane rufflings
Taipale et al., J Biol Chem 1996 : Immunoprecipitation analysis indicated that HGF prevented the suppression of Cdk4 and Cdk2, but not the induction of p21 , by TGF-beta1