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AKT1 — CDKN1A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Mitsuuchi et al., Cancer Res 2000
(Ovarian Neoplasms) :
In addition, overexpression of wild-type or constitutively active
AKT in A2780 cells sustained the regulation of p21 induction or
increased the level of
p21 expression, respectively
Lawlor et al., Mol Cell Biol 2000
:
Here we show that IGF-I promotes muscle cell survival through
Akt mediated induction of the cyclin dependent kinase inhibitor
p21
Zhou et al., Nat Cell Biol 2001
(Adenocarcinoma...) :
Our results indicate that HER-2/neu
induces cytoplasmic localization of
p21Cip1/WAF1 through activation of
Akt to promote cell growth, which may have implications for the oncogenic activity of HER-2/neu and Akt
Pavelić et al., J Mol Med (Berl) 2001
(Body Weight...) :
In vitro tissue culture studies showed that finely ground clinoptilolite inhibits
protein kinase B ( c-Akt ),
induces expression of
p21WAF1/CIP1 and p27KIP1 tumor suppressor proteins, and blocks cell growth in several cancer cell lines
Schönherr et al., J Biol Chem 2001
:
Involvement of
Akt/protein kinase B in up-regulation of
p21 ( WAF1/CIP1 ) but not p27 ( KIP1 ) ... Overexpression of dominant negative
Akt inhibited the decorin mediated induction of
p21 and cyclin A, but had no effect on p27
Li et al., J Biol Chem 2002
:
AKT/PKB phosphorylation of p21Cip/WAF1
enhances protein stability of
p21Cip/WAF1 and promotes cell survival
Vancurova et al., J Virol 2002
(Laryngeal Neoplasms...) :
Increased NF-kappaB activity and cytoplasmic accumulation of
p21 ( CIP1/WAF1 ) might counteract death promoting effects elicited by overexpressed PTEN and
reduced activation of
Akt and STAT3 previously noted in these tissues
Rössig et al., J Biol Chem 2002
:
Signaling via the phosphoinositide 3-kinase (PI3K)/AKT pathway is crucial for the regulation of endothelial cell ( EC ) proliferation and survival, which involves the
AKT dependent phosphorylation of the DNA repair protein
p21 ( Cip1 ) at Thr-145
Hiromura et al., Kidney Int 2002
:
Our results also showed that the CDK-inhibitor p21 was increased by insulin and that
p21 up-regulation was
PI3-kinase/Akt pathway
dependent
Schönherr et al., Ann N Y Acad Sci 2002
:
Induction of dominan negative
Akt by a replication-deficient adenovirus
blocked p21 and cyclin A synthesis, but had no effect on p27
Héliez et al., Oncogene 2003
(Neoplasms) :
This cytoplasmic accumulation of p21 resulted from an
AKT dependent
p21 phosphorylation leading to an association of p21 with 14-3-3 ... Furthermore, the cytoplasmic
p21 accumulation observed in PTX treated cells was
inhibited by LY 294002, a specific PI-3 kinase inhibitor or by the expression of a dominant negative
AKT mutant
Rahmani et al., Oncogene 2003
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of
p21 ( CIP1/WAF1 ) induction rather than
AKT inhibition
Comalada et al., Eur J Immunol 2004
:
PI-3K inhibitors also block growth factor dependent expression of
p21 ( Waf1 ) and the
activation of
Akt
Kokkinakis et al., J Neuropathol Exp Neurol 2004
(Cell Transformation, Neoplastic) :
Western blot analyses demonstrated that MNU exposure caused progressive reduction of
p21 protein levels, an increase of Rb phosphorylation,
activation of
AKT and CDK2, and upregulation of FGF receptors
Rattan et al., J Biol Chem 2005
(Neoplasms, Experimental) :
Moreover, constitutive active AMPK arrested the cells in S-phase by inducing the expression of
p21 , p27, and p53 proteins and
inhibiting Akt phosphorylation, suggesting the involvement of AMPK
Lu et al., Int J Oncol 2006
(Prostatic Neoplasms) :
PI3K-Akt signaling is
involved in the regulation of
p21 ( WAF/CIP ) expression and androgen independent growth in prostate cancer cells
Hauck et al., Circ Res 2007
(Hypertrophy) :
Lovastatin also stimulates protein kinase B/Akt kinase activity, and
Akt dependent phosphorylation forces
p21 in the cytoplasm, where it inhibits Rho-kinases contributing to the suppression of cardiomyocyte hypertrophy
Xia et al., J Biol Chem 2007
(Neoplasms) :
Collectively, these findings demonstrate that
p21 ( RAS ), through its downstream effector PI3K, induces PKCdelta expression and that this increase in PKCdelta activity, acting through
Akt , is
required for cell survival
Harms et al., J Neurosci 2007
:
Phosphatidylinositol
3-Akt-kinase dependent phosphorylation of
p21 ( Waf1/Cip1 ) as a novel mechanism of neuroprotection by glucocorticoids
Wu et al., Sheng Wu Gong Cheng Xue Bao 2007
:
[ The
effect of
protein kinase B on the expression and location of
p21 in early development of mouse fertilized eggs ] ... To investigate the
effect of
Protein kinase B on the expression and location of
p21 in mouse early development
Chiang et al., Mol Cancer Ther 2007
:
Examination of the Akt/mammalian target of rapamycin (mTOR) signaling revealed that this signaling was only transiently inhibited by low doses of luteolin, which suggested that the inability to cause sustained
Akt/mTOR inhibition may
contribute to
p21 induction and provide a survival advantage to HER2 overexpressing cancer cells
Wang et al., PloS one 2007
:
Furthermore, we show here a novel mechanism for NRP-1-specific control of the anti-apoptotic pathway in EC through involvement of the NRP-1 interacting protein ( NIP/GIPC ) in the activation of
PI-3K/Akt and subsequent inactivation of p53 pathways and FoxOs, as well as
activation of
p21
Park et al., Int J Radiat Oncol Biol Phys 2008
(Carcinoma, Non-Small-Cell Lung...) :
Combination of PTEN and gamma ionizing radiation enhances cell death and G ( 2 ) /M arrest through regulation of
AKT activity and
p21 induction in non-small-cell lung cancer cells
Heo et al., Growth Factors 2008
:
Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing
p21cip1/waf1 and p27kip1, which were
blocked by the inhibition of
Akt , mTOR and Notch
Festuccia et al., Endocr Relat Cancer 2009
(Disease Models, Animal...) :
In vivo, azacitidine ( 0.8 mg/kg i.p. ) reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16INKA, Bax, Bak,
p21/WAF1 , and p27/KIP1, and
inhibiting the activation of
Akt activity and the expression of cyclin D1, Bcl-2, and Bcl-XL
Shabbeer et al., Cancer Biol Ther 2009
(Breast Neoplasms...) :
Molecular changes induced in PCa cells are : in DU-145 cells : downregulation of mutant p53, and in PC-3 cells upregulation of
p21 and inhibition of TGFbeta
induced phosphorylation of
Akt
Guan et al., J Invest Dermatol 2009
:
However, neither Nckalpha nor Nckbeta was required for the activation of the PDGF receptor,
p21 activated protein kinase ( Pak1 ),
AKT , extracellular signal regulated kinase ( ERK ) 1/2, or p38MAP by PDGF-BB
Lee et al., Clin Cancer Res 2009
(Mammary Neoplasms, Experimental) :
Mixed tocopherols increased the expression of
p21 , p27, caspase-3, and peroxisome proliferator activated receptor-gamma, and
inhibited AKT and estrogen signaling in mammary tumors
Lee et al., Mol Cells 2009
:
Lf ( Fe ( 3+ ) ) immediately induced
Akt phosphorylation at Ser473, which subsequently
induced the phosphorylation of two G1-checkpoint Cdk inhibitors,
p21 ( Cip/WAF1 ) and p27 ( kip1 )
Suh et al., Biochem Biophys Res Commun 2009
:
Here, we demonstrate that the PP2Cgamma induced degradation of
p21 ( Cip1/WAF1 ) is
mediated by
Akt signaling
Kim et al., Phytomedicine 2010
(Breast Neoplasms) :
Finally, adenoviral constitutively
active-Akt ( Ad-CA-Akt ) overexpression
regulated the up-regulation of cyclin B1 and the down-regulation of
p21
Vaid et al., Carcinogenesis 2010
(Cell Transformation, Neoplastic...) :
Western blot analysis revealed that honokiol : ( i ) inhibited the levels of cyclins D1, D2 and E and associated cyclin dependent kinases (CDKs)2, CDK4 and CDK6, ( ii ) upregulated
Cip/p21 and Kip/p27 and ( iii )
inhibited the levels of phosphatidylinositol 3-kinase and the phosphorylation of
Akt at Ser ( 473 ) in UVB induced skin tumors
Li et al., Biomed Environ Sci 2010
:
CagA ( + ) H. pylori induces
Akt1 phosphorylation and
inhibits transcription of
p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) via PI3K/Akt1 pathway ... Activation of
PI3K/Akt1 pathway and subsequent negative
regulation of
p21 ( WAF1/CIP1 ) and p27 ( KIP1 ) expression might be involved in CagA associated carcinogenesis
Moon et al., Cell Mol Life Sci 2011
:
Akt mediated phosphorylation of
p21 and protection of apoptosis are completely abolished by inhibitors of PI3K and Akt
Yohn et al., BMC urology 2011
(Carcinoma, Transitional Cell...) :
PI3-kinase and
AKT cause an upregulation of
p21 by suppressing GSK-3ß activity and activating mTOR in both cultured human urothelial carcinoma cells and mouse urothelial cells in vivo
Christgen et al., Lab Invest 2012
(Breast Neoplasms...) :
These genes included
CDKN1A , MDM2 and PHLDA3, a recently described p53-inducible
inhibitor of
AKT
Yajima et al., J Dermatol Sci 2012
(Melanoma) :
Proliferation of GNG2 overexpressed SK-Mel28 human malignant melanoma cells was suppressed with decreased c-SRC and
AKT activities and
increased p21 ( Cip/WAF1 ) expression level in vitro
Chou et al., Br J Pharmacol 2013
:
Overexpression of
AKT1 , but not of AKT2,
induced p21/p27 phosphorylation and increased cytosolic
p21/p27 levels, as did homocysteine treatment
Rokudai et al., Proc Natl Acad Sci U S A 2013
(Leukemia, Promyelocytic, Acute) :
As a
result of PML mediated suppression of
Akt , the increased PML-MOZ interaction enhances
p21 expression and induces p53 dependent premature senescence upon forced PML expression
De Santi et al., Anticancer Res 2013
(Breast Neoplasms) :
Background/Aim : The indole-3-carbinol cyclic tetrameric derivative ( CTet ) inhibits breast cancer cell proliferation by endoplasmic reticulum stress and autophagy related cell death induction,
AKT/PKB ( protein kinase B ) activity
inhibition and p53 independent overexpression of
cyclin dependent kinase inhibitor-1A ( p21/CDKN1A )
Cordero-Herrera et al., Nutr Cancer 2013
:
Exposure of SW480 cells to ECG also led to apoptosis as determined by time dependent changes in caspase-3 activity, MAPKs [ extracellular regulated kinase (ERK), p38, and c-jun amino-terminal kinase ( JNK ) ],
p21 and p53 activation, and
AKT inhibition
Genot et al., Oncogene 1998
:
In contrast,
p21ras signals are unable to
induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR