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FGF11 — STAT1
Text-mined interactions from Literome
Sahni et al., Genes Dev 1999
:
FGF treatment of RCS cells
induces phosphorylation of
STAT-1 , its translocation to the nucleus, and an increase in the expression of the cell-cycle inhibitor p21WAF1/CIP1
Krejci et al., J Cell Sci 2008
:
However, as demonstrated by western blotting with phosphorylation-specific antibodies, imaging of STAT nuclear translocation, STAT transcription factor assays and STAT luciferase reporter assays,
FGF does not
activate STAT1 or STAT3 in RCS chondrocytes, which nevertheless respond to a FGF stimulus with potent growth arrest
Krejci et al., Cell Signal 2009
:
Despite the accumulation, both endogenous and cytokine induced activation of
STAT1 and STAT3 is
impaired by
FGF , as demonstrated by imaging of active STAT nuclear translocation and analyses of STAT activatory phosphorylation and transcriptional activation
Johnson et al., Oncogene 1998
(Breast Neoplasms...) :
FGF signaling
activates STAT1 and p21 and inhibits the estrogen response and proliferation of MCF-7 cells