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JARID2 — YY1

Text-mined interactions from Literome

Shen et al., Cell 2009 : In vitro JMJ inhibits PRC2 methyltransferase activity, consistent with increased H3K27me3 marks at PRC2 targets in Jmj ( -/- ) ESCs ... Paradoxically, JMJ is required for efficient binding of PRC2 , indicating that the interplay of PRC2 and JMJ fine-tunes deposition of the H3K27me3 mark
Li et al., Genes Dev 2010 : Jarid2 can bind DNA and its recruitment in ES cells is interdependent with that of PRC2, as Jarid2 knockdown reduced PRC2 at its target promoters, and ES cells devoid of the PRC2 component EED are deficient in Jarid2 promoter access