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MLF1 — TP53

Text-mined interactions from Literome

Yoneda-Kato et al., EMBO J 2005 (Leukemia, Myeloid) : Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3
Yoneda-Kato et al., Mol Cell Biol 2008 (Neoplasms) : Myeloid leukemia factor 1 (MLF1) stabilizes the activity of the tumor suppressor p53 by suppressing its E3 ubiquitin ligase, COP1, through a third component of the COP9 signalosome ( CSN3 ) ... Here we show that MLF1 is a cytoplasmic-nuclear shuttling protein and that its nucleolar localization on fusing with NPM prevents the full induction of p53 by both genotoxic and oncogenic cellular stress