Fujita et al., Blood 2006
(Endotoxemia...) :
Unlike normal DCs, which produced proinflammatory cytokines in response to bacterial lipopolysaccharide (LPS), DC ( regs ) produced fewer proinflammatory cytokines and instead preferentially produced interleukin-10 (IL-10), and these events involved the expression of IkappaBNS and Bcl-3 as well as cyclic AMP ( cAMP ) -mediated activation of protein kinase A (PKA) Venkataraman et al., Mol Immunol 1998
:
PKA-activation caused a downregulation of anti-IgM induced expression of Bcl-xL protein, that was restored by IL-4