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PARP1 — RASA1

Text-mined interactions from Literome

Jordan et al., J Biol Chem 1999 : Expression of chick Rap1GAP in PC-12 cells inhibited activation of Rap1 by forskolin
McLeod et al., J Immunol 2002 : Moreover, blocking the activation of Rap1 and Rap2 via the expression of a Rap-specific GTPase activating protein significantly reduced the ability of B cells to migrate toward SDF-1
Nur-E-Kamal et al., Mol Biol Cell 1992 : The GAP1 ( also called Ras GAP ) is highly specific for Ras and does not stimulate the intrinsic GTPase activity of Rap1 or Rho
Schultess et al., Blood 2005 : Phosphorylation of Rap1GAP2 by cGKI might mediate inhibitory effects of NO/cGMP on Rap1
Maruta et al., J Biol Chem 1991 : In this paper, we describe the enzymatic properties of several mutated Rap1A and chimeric Ras/Rap1A ( or -1B ) proteins which lead to the following conclusions : ( i ) the GAP3 dependent activation of both Rap1A and -1B GTPases requires Gly12, but neither Thr61 nor Gln63 ; ( ii ) residues 64 to 70 of the Rap1 GTPases are sufficient to determine their specificities for GAP3 ; and ( iii ) residues 61 to 65 of the Ras GTPases are sufficient for determining their specificities for GAP1
Nellore et al., J Clin Endocrinol Metab 2009 (Carcinoma, Papillary...) : Rap1 GTPase activating protein (GAP) regulates the activity of Rap1 , a putative oncogene ... In vitro, loss of Rap1GAP was sufficient to increase Rap1 activity in thyroid cells
Zheng et al., Cancer Res 2009 (Melanoma) : In the present study, we show that expression of Rap1GAP , a specific negative regulator of Rap1 , is decreased in human melanoma tumors and cell lines ... Overexpression of Rap1GAP in melanoma cells blocks Rap1 activation and extracellular signal regulated kinase ( ERK ) phosphorylation and inhibits melanoma cell proliferation and survival
Zuo et al., Cancer Res 2010 (Carcinoma, Papillary, Follicular...) : Rap1GAP , a Rap1 GTPase activating protein, inhibits the RAS superfamily protein Rap1 by facilitating hydrolysis of GTP to GDP
Frech et al., Science 1990 : Rap1A-p21 was not activated by GAP but bound tightly to GAP and was an effective competitive inhibitor of GAP mediated Ras-GTPase activity
Janoueix-Lerosey et al., Biochem Biophys Res Commun 1994 : This phosphorylation does not affect the stimulation of the GTPase activity of Rap1 by Rap1GAP but may play a role in regulating the interaction of Rap1GAP with other proteins involved in the cellular functions regulated by Rap1 and Rap1GAP