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NOS3 — PPARG
Text-mined interactions from Literome
Neve et al., Biochem Pharmacol 2000
(Arteriosclerosis) :
PPAR gamma activation in macrophages and foam cells
inhibits the expression of activated genes such as inducible
nitric oxide synthase , matrix metalloproteinase-9 and scavenger receptor A. PPAR gamma may also affect the recruitment of monocytes in atherosclerotic lesions as it is involved in the expression of VCAM-1 and intracellular adhesion molecule-1 in vascular endothelial cells
Goetze et al., Hypertension 2002
:
Both
PPARgamma-ligands inhibited leptin stimulated Akt and
eNOS phosphorylation, but neither attenuated ERK 1/2 activation in response to leptin
Mendez et al., Hypertension 2003
:
PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible
nitric oxide synthase in cardiac myocytes
Crosby et al., J Pharmacol Exp Ther 2005
:
Peroxisome proliferation activated receptor ( PPAR)gamma is not necessary for synthetic
PPARgamma agonist
inhibition of inducible
nitric-oxide synthase and nitric oxide
Shankaranarayanan et al., Cancer Cell 2009
(Breast Neoplasms) :
This `` rexinoid apoptosis '' involves
activation of both iNOS and
eNOS by
RXR-PPARgamma and results in production of apoptogenic NO
Ricote et al., Nature 1998
:
Here we show that PPAR-gamma is markedly upregulated in activated macrophages and inhibits the expression of the inducible
nitric oxide synthase , gelatinase B and scavenger receptor A genes in
response to 15d-PGJ2 and synthetic
PPAR-gamma ligands