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AGTR2 — NOS3

Text-mined interactions from Literome

Ritter et al., FASEB J 2003 : AT2 receptor activation regulates myocardial eNOS expression via the calcineurin-NF-AT pathway ... Inhibition of the AT1-receptor did not reduce AngII mediated eNOS protein expression, whereas AT2 stimulation increased it 2.4-fold and AT2 inhibition suppressed it ... The modulatory effects of the AT2-receptor on eNOS expression was confirmed in mice with a genetic deletion of the AT2-receptor ( AT2-KO )
Yayama et al., Hypertension 2006 : These results suggest that the activation of AT2 receptor by Ang II induces phosphorylation of eNOS at Ser633 and Ser1177 via a PKA mediated signaling pathway, resulting in sustained activation of eNOS
Li et al., Am J Physiol Cell Physiol 2007 (MAP Kinase Signaling System) : Angiotensin II type 2 receptor dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway ... Collectively, these data suggest that G alpha ( i3 ), Shc, Grb2, Ras, and Raf-1 link Src to activation of MAPK and to the AT(2) dependent increase in eNOS expression in PAECs
Ratliff et al., Pediatr Res 2010 : AT1 and AT2 receptor blockade significantly attenuated NOS activity and eNOS expression at all ages, but nNOS expression only in developing afferents
Wang et al., Apoptosis 2012 : Overexpression of AT1R and AT2R markedly increased IL-1ß ( AT2R > AT1R ), iNOS ( AT2R > AT1R ) and eNOS expression