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IRF6 — TLR1

Text-mined interactions from Literome

Becker et al., J Biol Chem 2000 : Furthermore, we demonstrate TLR mRNA in hTBE cells and NF-kappa B activation following LPS
Inamori et al., J Endotoxin Res 2000 : Recent evidence has shown that a mammalian Toll-like receptor ( TLR ) is activated by bacterial lipopolysaccharides (LPS)
Ingalls et al., J Endotoxin Res 2000 : Specifically, TLR4 mediates LPS responses while TLR2 plays a broader role in the recognition of a variety of bacteria and bacterial antigens
Martin et al., J Immunol 2001 : Thus, E. coli and P. gingivalis LPS differentially affect CD14 and TLR expression as well as secondary LPS associated responses
An et al., Immunology 2002 : These results demonstrated that TLR2, TLR4 and TLR9 gene expression was differently regulated by LPS in mouse immature DC ... Up-regulation of TLR2, TLR4 and TLR9 expression by LPS might promote the overall responses of DC to bacteria and help to explain the synergy between LPS and other bacterial products in the induction of cytokine production
Geijtenbeek et al., J Exp Med 2003 : Both mycobacteria and LPS induce DC maturation through Toll-like receptor ( TLR ) signaling, suggesting that DC-SIGN, upon binding of ManLAM, interferes with TLR mediated signals
Köllisch et al., Immunology 2005 : The TLR ligands peptidoglycan, Pam3Cys and flagellin which bind to TLR2, TLR1/TLR2 heterodimer, and TLR5, respectively, also induced IL-8 secretion, whereas no IL-8 was induced by LPS , R-848, loxoribine and cytosine guanine dinucleotide containing oligodeoxynucleotide
Ren et al., J Periodontal Res 2005 : E. coli LPS induced the messages expression of MD-2, TLR-2 and -4
McKimmie et al., J Neuroimmunol 2005 (Alphavirus Infections...) : N2a neuroblastoma cells expressed TLR 3 but demonstrated no change in TLR gene expression in response to either LPS or virus infection
Møller et al., Cytokine 2005 : E. coli-LPS and LTA induced a dose dependent increase of CD14, TLR2 and TLR4 expression on monocytes in whole blood
Maris et al., Eur Respir J 2006 : The current study was designed to determine the effect of LPS on TLR gene expression in human alveolar macrophages in vivo
Foster et al., J Leukoc Biol 2007 : Although there was differential induction of TLR expression by LPS from P. gingivalis and E. coli, VIP inhibited the action of both of these LPS types on monocytes
Hajishengallis et al., Cell Microbiol 2006 : In summary, TLR2 activation by P. gingivalis LPS or fimbriae involves differential dependence on accessory signalling or ligand binding receptors, which may differentially influence innate immune responses
Tsujimoto et al., Immunol Lett 2006 : Although poly ( I:C ) and LPS induced differential dendritic cell ( DC ) cytokine profiles and toll-like receptor ( TLR ) expression, all were capable of causing phenotypic and functional DC maturation
Nhu et al., J Endotoxin Res 2006 : Transcriptional regulation of lipopolysaccharide (LPS) induced Toll-like receptor ( TLR ) expression in murine macrophages : role of interferon regulatory factors 1 (IRF-1) and 2 ( IRF-2 )
Liang et al., J Immunol 2007 (Acute Disease...) : We further found that the induction of the negative regulators of TLR signaling IL-1R associated kinase-M, Toll interacting protein, and A20 by intratracheal LPS in vivo and in macrophages in vitro was significantly reduced in CD44 ( -/- ) mice
Maratheftis et al., Clin Cancer Res 2007 (Myelodysplastic Syndromes) : Tumor necrosis factor involvement in the constitutive and lipopolysaccharide (LPS) induced TLR expression was also evaluated
Dye et al., J Immunol 2007 : Thus, LPS mediated TLR engagement produces an alternate pathway for BCR triggered signal propagation that differs from the classical, signalosome dependent pathway
Siracusa et al., J Immunol 2008 : Exposure of bone marrow derived dendritic cells to E2 also enhanced production of IL-12 in response to the TLR ligands, CpG and LPS
Salminen et al., Pediatr Res 2008 (Fetal Death...) : In uterus, placenta, and fetal membranes, LPS mostly increased the expressions of TLR , SPs, and cytokines
Shimada et al., Development 2008 : The toll-like receptor ( TLR ) system is expressed in cumulus cells of ovulated cumulus-oocyte complexes ( COCs ) and is activated by bacterial lipopolysaccharides (LPS)
Moon et al., Toxicol Appl Pharmacol 2008 : However, inflammatory tolerance was not mediated by the attenuated NF-kappaB activation which has been generally recognized as the major mediator of LPS mediated toll-like receptor ( TLR ) signaling pathway
Zhao et al., Proc Natl Acad Sci U S A 2008 (Virus Diseases) : Our study reveals that the ensuing inflammatory reaction after d-GalN sensitization reflects preferential toxicity of d-GalN to adult liver cells, rather than accurately reflecting the TLR response to LPS
Buttenschoen et al., Langenbecks Arch Surg 2009 (Acute-Phase Reaction...) : Endotoxemia, capability of plasma to inactivate endotoxin, cytokine release of LPS stimulated mononuclear cells, quantitative TLR mRNA expression, and plasma concentrations of TNFalpha, IL-6, C-reactive protein (CRP), alpha ( 1 ) -acid glycoprotein, transferrin, and albumin were measured
Wong et al., Eur J Immunol 2008 : This effect was observed during an antigen-specific interaction between DC and activated CD8 T cells, along with secondary TLR stimulation of DC by LPS
Wang et al., Acta Pharmacol Sin 2009 (Inflammation) : LPS induced membrane bound CD14, TLR4/CD14 complex levels and elevation of inflammatory cytokines were all significantly reduced by pre-incubation of fenoterol ( P < 0.05 )
Arsenault et al., J Recept Signal Transduct Res 2009 : For example, TLR4 is activated by lipopolysaccharide (LPS) , whereas TLR9 responds to microbial DNA ( CpGs )
Wang et al., Dev Comp Immunol 2010 (Bacterial Infections) : LPS and PolyIC were also potent inducers of tIL-17C2
Yao et al., Nitric Oxide 2010 (Demyelinating Diseases...) : The human transformed oligodendrocyte cell line, MO3.13 cells, express Toll like receptor genes ( TLR ) genes and are activated by lipopolysaccharide (LPS)
Ingerslev et al., PloS one 2010 : LPS was overall the strongest inducer of IL-1beta, IL-8, IL-10, TLR-3 and TLR-9
Nerren et al., Vet Immunol Immunopathol 2010 (Poultry Diseases) : The aim of the present study was to gain better insight into the nature of the ligand for TLR15 by characterizing gene expression patterns of TLR15 by heterophils in response to numerous bacterial derived TLR agonists LPS , flagellin, CpG oligodeoxynucleotides, lipotechoic acid (LTA), peptidoglycan ( PGN ), and Pam3CSK4 (PAM), stimulation with live Salmonella enterica serovar Enteritidis ( SE-used as a positive control ), chicken isolates of Escherichia coli ( EC ) and Enterococcus gallinarum ( EG ), the equine-specific pathogen Rhodococcus equi, and stimulation with heat killed, and formalin killed SE, EC, and EG
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Atzei et al., J Biol Chem 2010 : We now describe the first functional characterization of the human ortholog of Cactin ( hCactin ) and show that it acts as a negative regulator of TLRs. Overexpression of hCactin suppresses TLR induced activation of NF-?B and interferon-regulatory factor transcription factors and induction of TLR-responsive genes, whereas knockdown of endogenous hCactin augments TLR induction of these responses
den Hartog et al., PloS one 2011 : Recombinant bovine IL-10 inhibited TLR induced activation of monocytes, and dose-dependently inhibited LPS induced activation of monocyte derived DCs comparable to human IL-10
Naranjo-Gómez et al., Journal of translational medicine 2011 : Interestingly, in all cases, the cytokine secretion profiles of tol-DCs were not modified by a subsequent TLR stimulation with LPS , indicating that all products had stable phenotypes
Irie et al., J Periodontol 2012 : The purpose of the present study is to examine the combined effects of sodium hydrogen sulfide ( NaHS, an H ( 2 ) S donor drug ) and LPS on osteoclast differentiation and TLR expression in rat periodontal tissue
Laplante et al., J Biol Chem 2011 : A number of mammalian proteins ( termed `` endogenous Toll-like receptor ( TLR ) ligands '' ) have been reported to bind to TLR4, but, in most cases, subsequent studies have shown that LPS interaction with these proteins is responsible for TLR activation
Nakayama et al., Arthritis Res Ther 2012 (Arthritis, Experimental...) : Stimulation of TLR signaling with LPS appeared indispensable for activating the IL-32a-TNFa axis in vivo
Harder et al., J Clin Periodontol 2012 : Samples were assayed for gene expression levels of toll-like receptor 4 (TLR4), TLR9, interleukin (IL)-1ß, nuclear factor ` kappa-light-chain-enhancer ' of activated B-cells ( NF-kB ), tumour necrosis factor (TNF)-a, and Fas associated protein with death domain ( FADD ) as indicators of surface contamination resulting in lipopolysaccharides (LPS) stimulated TLR- or TNF mediated immune responses
White et al., Arterioscler Thromb Vasc Biol 2012 (Inflammation) : We investigated the effects of LPS on the Toll-like receptor ( TLR ) signaling pathway in 4F-differentiated monocyte derived macrophages
Thota et al., Reprod Sci 2013 : In the presence of LPS , vitamin D caused dose dependent decreases in the messenger RNA expression of MCP-1, IL-1ß, IL-13, TNF-a, TLR-4 , and TLR-5, the contractile associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells ... Western analysis showed that vitamin D decreased MCP-1, TLR-4 , and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1ß
Berthet et al., Clin Immunol 2012 : Upon stimulation of platelets with both Escherichia coli O111 and Salmonella minnesota LPS , the platelet LPS : : TLR4 interaction activated pathways to trigger the production of a large number of molecules
Chakraborty et al., Mol Immunol 2013 : TLR2, TLR4 or RAGE knockdown macrophages effectively inhibited the rHMGB1+PGN or LPS induced NO synergy
Wu et al., PloS one 2013 : We showed that the hADSCs expressed Toll-like Receptors (TLR) 1 , TLR2, TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2), Interleukin-1ß (IL-1ß), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) )
Jain et al., Infect Immun 2013 (Inflammation) : Instead, activation of TLR2 and TLR2/TLR1 by LPS is in large part due to copurifying molecules that are sensitive to the action of the enzyme lipoprotein lipase
Peng et al., Science signaling 2013 : DAP12 inhibits Toll-like receptor ( TLR ) signaling, such as that of TLR4 in response to its ligand lipopolysaccharide (LPS) , as well as cytokine responses by coupling to TREM2 ( triggering receptor expressed on myeloid cells 2 ) at the plasma membrane