Gene interactions and pathways from curated databases and text-mining

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IRF6 — NPPA

Text-mined interactions from Literome

Kürüm et al., Acta Cardiol 2003 (Coronary Artery Disease) : IRF resulting from asynergy and asynchrony in VVI mode pacemakers versus DDD mode pacemakers affects the plasma levels of ANP and BNP compared to renin and aldosteron
Xing et al., Microvasc Res 2010 (Inflammation) : Consistent with protective effects on EC permeability and monolayer integrity, ANP dramatically attenuated activation of inflammatory signaling by LPS and TNFalpha in pulmonary EC ... These results strongly suggest inhibitory effects of ANP on the LPS and TNFalpha induced inflammatory signaling as additional mechanism of EC barrier preservation in the models of acute lung injury and sepsis
Xing et al., Microvasc Res 2012 (Disease Models, Animal...) : This study examined regulation of ANP and its receptors NPR-A, NPR-B and NPR-C by LPS and involvement of ANP receptors in the modulation of LPS induced lung injury ... LPS stimulation significantly increased mRNA expression levels of ANP and NPR-A in pulmonary EC