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IRF6 — LEP

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Chautard et al., Neuroendocrinology 1999 (Body Weight) : Interestingly, the acute stimulation of leptin secretion by LPS in ADX + CB rats was qualitatively similar to that of intact controls on D1, but plasma leptin levels were significantly reduced on D3 and 5 compared to controls
Francis et al., Brain Res 2000 (Anorexia) : In contrast, the LPS induced increase in leptin levels reached a maximum at 210 min and remained elevated even at the end of the observation period
Mastronardi et al., Neuroimmunomodulation 2000 : To test the hypothesis that LPS would also stimulate the release of leptin , LPS ( 0.6 mg/kg ) was injected intravenously into conscious male rats bearing external jugular venous catheters ... The lower dose decreased plasma leptin slightly, whereas the higher dose of NAME increased plasma leptin at 110 min but had no effect on LPS induced leptin release ... On the other hand, dexamethasone ( DEX ) ( 0.85 mg/kg ), a synthetic glucocorticoid, injected 15 min before LPS, decreased LPS induced leptin release by 80 % ( p < 0.001 ) ... The results indicate that LPS is a stimulant of leptin release, that NO has little control over basal or LPS induced leptin release, but that glucocorticoids, epitomized by DEX, largely block LPS induced leptin release
Mastronardi et al., Proc Natl Acad Sci U S A 2001 : Anesthesia largely blunted the LPS induced leptin release at 120 min. Isoproterenol ( beta-adrenergic agonist ) failed to alter plasma leptin but reduced LPS induced leptin release significantly ... alpha-Bromoergocryptine ( dopaminergic-2 receptor agonist ) decreased plasma leptin ( P < 0.01 ) and blunted the LPS induced rise in plasma leptin release ( P < 0.001 ) ... Because alpha-bromoergocryptine decreased basal and LPS induced leptin release, dopaminergic neurons may inhibit basal and LPS induced leptin release by suppression of release of prolactin from the adenohypophysis
Soop et al., Am J Physiol Endocrinol Metab 2002 (Diabetes Mellitus, Type 2...) : In vitro studies showed no modulation of LPS stimulated IL-6 or TNF-alpha production by glucose, insulin, or leptin at physiologically relevant concentrations
Soliman et al., Jpn J Vet Res 2002 (Acute Disease...) : We previously reported no effect of LPS on serum leptin levels in sheep, despite marked anorexia and fever
Brzozowski et al., J Pharmacol Exp Ther 2004 (Stomach Diseases) : Hp-LPS injected repeatedly suppressed the gastric acid secretion, up-regulated leptin mRNA and protein, and increased plasma leptin and gastrin levels
Sachot et al., J Physiol 2004 (Anorexia...) : Previous studies have demonstrated that LPS induces leptin synthesis and secretion in the periphery, and that the action of leptin on appetite suppression and fever are dependent on brain interleukin (IL)-1beta
Gómez-Ambrosi et al., FEBS Lett 2004 : Reduced adipose tissue mass and hypoleptinemia in iNOS deficient mice : effect of LPS on plasma leptin and adiponectin concentrations ... Leptin responsiveness to LPS in iNOS-/- mutants is preserved, showing that the LPS induced rise in leptin is independent of the presence of functional iNOS
Mastronardi et al., Neuroimmunomodulation 2005 (Bacterial Infections...) : Our results suggest that alpha-MSH increased leptin release without altering its synthesis, but when LPS increased release and synthesis of leptin , alpha-MSH, although further increasing release, blocked the enhanced synthesis of leptin elicited by LPS
Gayle et al., Life Sci 2006 (Anorexia...) : However LPS ( 6 h ) induced a greater percent increase in plasma leptin in female than male rats ( 230 vs. 33 %, p < 0.01 ), whereas ghrelin was similarly decreased in both females and males ( 66 vs. 44 % )
Hoareau et al., Cytokine 2006 (Inflammation) : Inversely, LPS strongly inhibits adipose cell leptin release, with PEA acting as a potentiator of this inhibitory effect
Spencer et al., Am J Physiol Regul Integr Comp Physiol 2007 (Acute Disease...) : Despite reductions in circulating leptin levels in response to LPS during the neonatal period, no long-term effects on leptin were seen
Yamano et al., Lab Invest 2010 (Alveolar Bone Loss...) : In this study, the effects of bLF on mRNA expression in lipopolysaccharide (LPS) stimulated osteoblasts (OBs) and on LPS induced osteoclastogenesis were examined ... The bLF inhibited the upregulation of TNF-alpha-mRNA- and upregulation of receptor activator of NF kappaB ( RANKL ) -mRNA expression and eliminated downregulation of osteoprotegerin (OPG)-mRNA expression in LPS stimulated OBs and reduced LPS induced osteoclastogenesis in co-culture with primary OBs and bone marrow cells
Iwasa et al., J Neuroimmunol 2011 : Five- and 15-day-old rats showed no leptin response and a weak hypothalamic IL-1ß response to LPS when compared with 25- and 42-day-old rats
Ciardi et al., Br J Nutr 2012 (Obesity) : As the daily intake of food additives has increased substantially, the aim of the present study was to investigate a potential influence of food additives on the release of leptin , IL-6 and nitrite in the presence of LPS in murine adipocytes
Pini et al., Cytokine 2013 (Endotoxemia...) : Plasma TNFa, IFN?, Galectin-3 and leptin were significantly elevated in response to LPS and were each differentially affected by obesity and/or IL-6 deficiency
Pohl et al., J Neuroendocrinol 2013 (Inflammation) : In cycling females, LPS induced a higher fever response in obese rats accompanied by higher circulating levels of IL-6 and IL-1ra, as well as an increase in circulating leptin only in the obese cycling group
Faggioni et al., Am J Physiol 1997 (Anorexia) : Recently, we reported that LPS and cytokines increase leptin levels in hamsters
Faggioni et al., Am J Physiol 1998 (Inflammation) : In IL-1 beta +/+ mice, both LPS and turpentine increased leptin mRNA and circulating leptin ... In contrast, neither LPS nor turpentine increased leptin levels in IL-1 beta -/- mice ... We conclude that IL-1 beta is essential for leptin induction by both LPS and turpentine in mice, but IL-6 is not
Finck et al., Endocrinology 1998 : To examine the role of tumor necrosis factor-alpha (TNF alpha) in mediating leptin secretion during an immunological challenge, we studied the effects of lipopolysaccharide (LPS) and TNF alpha on leptin secretion in endotoxin-sensitive C3H/HeOuJ ( OuJ ) mice, endotoxin-insensitive C3H/HeJ ( HeJ ) mice, and primary adipocytes cultured from both
Faggioni et al., Am J Physiol 1999 (Obesity) : Leptin is induced by lipopolysaccharide (LPS) and cytokines