◀ Back to IRF6

IDO1 — IRF6

Text-mined interactions from Literome

Currier et al., J Interferon Cytokine Res 2000 : Both LPS and TNF-alpha enhanced IDO activity and IDO mRNA expression, with maximal IDO induction at 100 ng/ml LPS or 5 ng/ml TNF-alpha ... Anti-TNF-alpha failed to neutralize the effects of LPS treatment, and insufficient TNF-alpha or IL-1 was produced by LPS treated THP-1 cells to account for the enhancing effect of LPS, indicating that the effect of LPS on IDO was independent of TNF-alpha and IL-1
Babcock et al., Cytokine 2000 : Interferon (IFN)-gamma induced indoleamine 2,3-dioxygenase (IDO) activity is enhanced synergistically by interleukin (IL-)1, tumor necrosis factor-alpha (TNF-alpha) and LPS in IFN treated macrophages by increasing IDO mRNA concentration
Wirleitner et al., J Leukoc Biol 2002 : Our results showed that IFN-gamma as well as LPS are inducers of IDO in DC
Orabona et al., Blood 2006 : Thus, IRF-8 is required in tolerogenic DCs for the positive regulation of Indo and the negative regulation of Tyrobp
Fujigaki et al., J Biochem 2006 : In this study, we explored whether lipopolysaccharide (LPS) or several proinflammatory cytokines can induce IDO via an IFN-gamma independent mechanism, and whether IDO induction by LPS requires the STAT1alpha and IRF-1 signaling pathways ... IDO was induced by LPS or IFN-gamma in peripheral blood mononuclear cells and THP-1 cells, and a synergistic IDO induction occurred when THP-1 cells were cultured in the presence of a combination of tumor necrosis factor-alpha, interleukin-6 or interleukin-1beta ... Further, the LPS induced IDO activity was inhibited by both p38 mitogen activated protein kinase ( MAPK ) and nuclear factor-kappaB (NF-kappaB) inhibitors ... These findings suggest that the induction of IDO by LPS in THP-1 cells is not regulated by IFN-gamma via recruitment of STAT1alpha or IRF-1 to the intracellular signaling pathway, and may be related to the activity of the p38 MAPK pathway and NF-kappaB
Mahanonda et al., J Immunol 2007 : HGF production of IDO in response to P. gingivalis LPS , IFN-gamma, or the two in combination inhibited T cell proliferation in MLRs
Jung et al., FEBS Lett 2007 : In this study, we investigated whether lipopolysaccharide (LPS) induces the expression of IDO through an IFN-gamma mediated signaling pathway or not ... However, LPS induced expression of IDO was inhibited by LY294002 and SP600125 but not by JAK inhibitor I, SB203580, or U0126 ... These findings clearly indicate that LPS can induce the IDO expression via an IFN-gamma independent mechanism and PI3 kinase and JNK in the LPS induced pathway leading to IDO expression
Connor et al., Neurosci Lett 2008 (Inflammation) : Similarly, in cultured glial cells LPS induced IDO expression was accompanied by increased TNF-alpha and IL-6 expression, whereas IFN-gamma was not detectable ... These findings indicate that IFN-gamma is not required for LPS induced IDO expression in brain
Wang et al., Brain Behav Immun 2010 : LPS induced indoleamine 2,3-dioxygenase is regulated in an interferon-gamma independent manner by a JNK signaling pathway in primary murine microglia ... Here we investigated the mechanism of IDO expression induced by LPS in primary cultures of microglia derived from neonatal C57BL/6J mice ... LPS ( 10 ng/ml ) induced IDO transcripts that peaked at 8h and enzymatic activity at 24h, resulting in an increase in extracellular kynurenine, the catabolic product of IDO induced tryptophan catabolism ... This IDO induction by LPS was accompanied by synthesis and secretion of the proinflammatory cytokines TNFalpha and IL-6, but without detectable IFNgamma expression ... To explore the mechanism of LPS induced IDO expression, microglia were pretreated with the c-Jun-N-terminal kinase (JNK) inhibitor SP600125 for 30 min before LPS treatment ... We found that SP600125 blocked JNK phosphorylation and significantly decreased IDO expression induced by LPS , which was accompanied by a reduction of LPS induced expression of TNFalpha and IL-6 ... Collectively, these data extend to microglia the property that LPS induces IDO expression via an IFNgamma independent mechanism that depends upon activation of JNK
Ohtaki et al., Biochem Biophys Res Commun 2009 (Peritonitis) : Interaction between LPS induced NO production and IDO activity in mouse peritoneal cells in the presence of activated Valpha14 NKT cells ... In this study, we demonstrated that lipopolysaccharide (LPS) markedly increased nitric oxide ( NO ) production and indoleamine 2,3-dioxygenase (IDO) activity in mouse peritoneal cells in the presence of activated Valpha14 natural killer T cells
Jung et al., Int Immunopharmacol 2010 : Additionally, PGE2 diminished the LPS induced IDO expression in DCs, thereby contributing to the inhibition of expression of the surface molecules ( CD80, CD86 and MHC class I ) and the production of the proinflammatory cytokines ( IL-12 p70 and TNF-alpha ) by LPS stimulation
Fu et al., Journal of neuroinflammation 2010 : LPS also increased IDO expression and induced depressive-like behavior, as measured by increased duration of immobility in the forced swim test
Saito et al., Int Arch Allergy Immunol 2011 (Churg-Strauss Syndrome...) : Stimulation of CD14+ monocytes with LPS or Pam3CSK reduced IDO expression by the cells from patients with relapsed CSS
Park et al., Exp Mol Med 2011 (Arthritis, Rheumatoid) : We demonstrate that both poly ( I:C ) and lipopolysaccharide (LPS) induce expression of IDO in synovial fibroblasts
Corona et al., Brain Behav Immun 2013 : Collectively these data indicate that LPS induced IDO activation contributes to persistent microglial activation and depressive-like behavior in CX3CR1 ( -/- ) mice
Carlin et al., J Leukoc Biol 1989 : However, the presence of lipopolysaccharide (LPS) in the culture medium was required for the maximum induction of IDO activity by IFN-beta
Daley-Yates et al., Toxicol Appl Pharmacol 1988 : The induction of IDO by bacterial lipopolysaccharide (LPS) was found to be 20-fold in the mouse and 4-fold in the rat, but did not confer protection against paraquat induced pulmonary toxicity
Sekkaï et al., Arch Biochem Biophys 1997 : Indoleamine 2,3-dioxygenase (IDO) and nitric oxide synthase (NOS) type II are induced in macrophages by interferon (IFN)-gamma and lipopolysaccharide (LPS)
Alberati-Giani et al., J Immunol 1997 : LPS and picolinic acid, two costimulatory agents that up-regulate inducible NOS in activated cells, regulated IDO induction differently in the two cell lines ... LPS and picolinic acid caused a significant decrease of IDO activity in IFN-gamma activated MT2 cells
Hissong et al., J Interferon Cytokine Res 1997 : The objectives of this study were to see if IL-1 also enhances IFN-beta induced IDO activity by increasing specific mRNA expression and to determine if lipopolysaccharide (LPS) enhances IFN induced IDO activity in a similar manner ... LPS alone induced IDO mRNA expression and also increased IDO mRNA expression induced by either type of IFN