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CYP3A — IRF6

Text-mined interactions from Literome

Pan et al., Drug Metab Dispos 2003 : These data clearly demonstrate that LPS mediated modulation of CYP3A11 , 2B10, 2C29, 1A2, and 4A10 in mouse liver is Stat1 independent
Xu et al., Free Radic Biol Med 2004 : The in vivo effects of lipopolysaccharide (LPS) on expression of PXR and its target gene cytochrome P450 3A (CYP3A) in mouse liver were investigated in this study ... LPS also represses the upregulation of CYP3A11 mRNA levels and erythromycin N-demethylase ( ERND ) catalytic activity in mice pretreated with PXR ligands dexamethasone, rifampicin, mifepristone, and phenobarbital ... These antioxidants also prevented the repressive effects of LPS on dexamethasone-, rifampicin-, mifepristone-, and phenobarbital-inducible CYP3A11 mRNA expression and ERND catalytic activity in mouse liver ... These results indicate that Kupffer cells contribute to LPS induced downregulation of PXR and CYP3A in mouse liver ... Reactive oxygen species, produced possibly by NADPH oxidase and perhaps by xanthine oxidase, are involved in LPS induced downregulation of nuclear receptor PXR and its target gene CYP3A in mouse liver
Xu et al., J Pineal Res 2005 : Our earlier study indicated that reactive oxygen species contribute to lipopolysaccharide (LPS) induced down-regulation of PXR and its target gene CYP3A in mouse liver ... In this study, we investigated the effects of melatonin on LPS induced down-regulation of PXR and CYP3A in mouse liver ... Repeated doses of melatonin ( 10 mg/kg ) treatments also significantly attenuated LPS induced down-regulation of dexamethasone-inducible CYP3A11 mRNA level and ERND activity in mouse liver ... These findings suggest that melatonin may exert its protective effects on LPS induced down-regulation of PXR and CYP3A via counteracting LPS induced oxidative stress in mouse liver
Chen et al., Toxicology 2005 : Lipopolysaccharide (LPS) induced downregulation of PXR, CYP3A and MDR1 in liver has been demonstrated in a series of studies ... However, it is not clear whether LPS represses the expression of PXR, CYP3A and MDR1 in placenta
Goralski et al., Am J Physiol Gastrointest Liver Physiol 2005 (Central Nervous System Diseases...) : The loss of Cyp3a11 in response to centrally or peripherally administered LPS could not be evoked in Toll-like receptor-4 (TLR4)-mutant ( C3H/HeJ ) mice, indicating that TLR4 signaling pathways are directly involved in the enzyme loss
Kato et al., Innate Immun 2008 (Disease Models, Animal...) : In this study, we investigated the effects of lipopolysaccharide (LPS) on hepatic total cytochrome P450 ( CYP ), CYP3A2 , and CYP2C11 contents in a transient, LPS induced, endotoxemia model of rats