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ALG1 — IRF6

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Anastassiadis et al., J Anim Breed Genet 1997 : In both lines, males produce more HBsAg than females, and in all cases the MT-I promoter can be induced by dexamethasone, lipopolysaccharide (LPS) , and heavy metals
Zheng et al., Neurochem Int 1995 : Northern blot analysis revealed that MT-I mRNA levels in liver were induced dramatically ( 12-27-fold over basal levels ) by all of the chemicals, while in brain only LPS produced an increase in MT-I mRNA ( 2-fold )
Carrasco et al., Brain Res Mol Brain Res 1998 : In situ hybridization analysis revealed that brain MT-I induction by bacterial lipopolysaccharide (LPS) was significantly lower in IL-6- and TNFR1-deficient mice, and to a greater extent in the double mutant mice, in most brain areas studied
Lee et al., Biochem J 1999 : Mechanisms of regulation of mouse metallothionein (MT)-I gene expression in response to bacterial endotoxin-lipopolysaccharide (LPS) were examined ... This study suggests that the effects of LPS on hepatic MT-I gene expression are mediated by IL-6 and involve the activation of STAT binding to the proximal promoter