Gene interactions and pathways from curated databases and text-mining

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AGTR2 — IRF6

Text-mined interactions from Literome

Wong et al., J Toxicol Environ Health 2002 : Nuclear factor kappaB (NF-kappaB) binding was increased at 2 and 8 h in cells subjected to synchronous and delayed synchronous VT exposure in the presence of LPS
Gupta et al., Mol Cell Biochem 2004 (Endotoxemia) : The data revealed that LPS induces MEPD-sensitive inflammatory response syndrome ( SIRS ) at 2- and 24 h post endotoxemia
Zhang et al., Inflammation 2008 (Inflammation) : To investigate the role of glutathione ( GSH ) synthesis in the regulation on nuclear factor (NF)-kappaB activity and tumor necrosis factor-alpha (TNF-alpha) release by glutamine ( GLN ) in lipopolysaccharide (LPS) stimulated alveolar type II (AT-II) epithelial cells of rat lungs ... Supplementation of GLN could increase the GSH level and attenuate the release of TNF-alpha in LPS stimulated AT-II cells in a dose-dependant manner ... As a precursor of GSH, glutamine could prevent the NF-kappaB activation and attenuate the release of TNF-alpha in LPS stimulated AT-II cells and the effect may be mediated via GSH synthesis
Scicluna et al., Eur J Pharmacol 2009 : At 2h in the presence of LPS , there was increased relaxation to ANP in arteries exposed to LPS [ 16.3+/-2.4 %, P < 0.05 ]
Stabile et al., Peptides 2010 (Endotoxemia) : LPS significantly increased plasma OT concentration at 2 and 4h post-injection
Wang et al., Experimental biology and medicine (Maywood, N.J.) 2012 (Inflammation) : Like Ang II, LPS increased the expression of AT1R, AT2R and LOX-1
Futran et al., J Immunol 1989 : Inhibition of protein synthesis with anisomycin or inhibition of transcription with actinomycin-D blocked the increased expression of TfR at 4 h. Northern blot analysis showed a marked increase of TfR mRNA at 2 and 4 h with either anti-mu or LPS which was then followed by an apparent decline at 16 h
Burnier et al., Br J Pharmacol 1995 : 5. The effect of LPS on the angiotensin II receptor was dose-, time- and protein-synthesis dependent and was associated with an increased expression of the receptor gene
Cheng et al., Naunyn Schmiedebergs Arch Pharmacol 1998 (Endotoxemia) : LPS reduced MAP, CO, RBF as well as MBF at 2.5 and 4 h, and increased TPR at 2.5 but not 4 h. Whereas MB alone had no effects on measured variables in control rats at 4 h, in LPS treated rats, it elevated TPR at all doses and attenuated the fall in MAP at the two low doses