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IRF1 — VCAM1

Text-mined interactions from Literome

Ochi et al., Eur J Immunol 2002 : Transcriptional up-regulation of the VCAM-1 gene, induced by proinflammatory cytokines such as IL-1beta and TNF-alpha, requires activation of not only NF-kappaB, but also involves interferon regulatory factor (IRF)-1 ... Taken together, hyperosmolarity selectively inhibits cytokine induced VCAM-1 in endothelial cells, via an IRF-1 dependent mechanism
Nizamutdinova et al., J Agric Food Chem 2009 : We found that IRF-1 and GATAs, especially GATA-4 and -6, were involved in the TNF-alpha mediated expression of VCAM-1 but not ICAM-1, and anthocyanins decreased nuclear levels of GATA-4 and GATA-6 as well as IRF-1
Lechleitner et al., J Exp Med 1998 : Nuclear IRF-1 is the molecular basis of IFN enhancement, because ( a ) IFN plus TNF treated cells displayed increased nuclear IRF-1 levels and increased IRF-1 binding to the VCAM-1 promoter, compared with cells treated with TNF alone ; ( b ) kinetics of nuclear IRF-1 levels correlated with VCAM-1 mRNA levels ; ( c ) transfection with an IRF-1 construct substituted for IFN treatment ; and ( d ) transfection with an expression construct encoding IRF-2, a competitive inhibitor of IRF-1, reduced TNF induced VCAM-1 expression