Gene interactions and pathways from curated databases and text-mining

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IL5 — LCK

Text-mined interactions from Literome

Kemp et al., J Immunol 2010 : Using a mouse model, we report that Lck is important in regulating the expression of IL-4 in Th2 skewed cells but is not as necessary for the expression of Th2 cytokines IL-5 , IL-10, and IL-13
Smeets et al., BMC immunology 2012 : Translation towards a primary, whole blood setting and purified human CD4+ T cells revealed that PMA/CD3 stimulation induced a more pronounced Th1 specific, Lck and PKC? dependent IFN? production, whereas PMA/CD28 induced Th2 specific IL-5 and IL-13 production, independent of Lck activation