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IL5 — LCK
Text-mined interactions from Literome
Kemp et al., J Immunol 2010
:
Using a mouse model, we report that
Lck is important in regulating the expression of IL-4 in Th2 skewed cells but is not as
necessary for the expression of Th2 cytokines
IL-5 , IL-10, and IL-13
Smeets et al., BMC immunology 2012
:
Translation towards a primary, whole blood setting and purified human CD4+ T cells revealed that PMA/CD3 stimulation induced a more pronounced Th1 specific, Lck and PKC? dependent IFN? production, whereas PMA/CD28
induced Th2 specific
IL-5 and IL-13 production, independent of
Lck activation