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H19 — IGF2

Text-mined interactions from Literome

Feinberg et al., Cancer Res 1999 (Neoplasms) : Our laboratory has found genomic imprinting of a large genomic domain of human 11p15.5, identifying six imprinted genes within this domain : ( a ) insulin-like growth factor II (IGF-II), an important autocrine growth factor in a wide variety of malignancies ; ( b ) H19 , an untranslated RNA that is a putative growth suppressor gene regulating IGF-II ; ( c ) p57KIP2, a cyclin dependent kinase inhibitor that causes G1-S arrest ; ( d ) KvLQT1, a voltage gated potassium channel ; ( e ) TSSC3, a gene that is homologous to mouse TDAG51, which is implicated in Fas mediated apoptosis; and (f) TSSC5, a putative transmembrane protein encoding gene
Naimeh et al., Endocr Res 2001 : This study was designed to characterize the ontogeny of H19 in sheep and the effect of maternal fasting on the expression of fetal IGF-II and H19 mRNA
Banerjee et al., TheScientificWorldJournal 2001 : On paternal inheritance, the methylated ICR silences the H19 gene and indirectly facilitates transcription from the distant Igf2 promoter, whereas on the maternal chromosome the unmethylated ICR, together with enhancers, activates transcription of the H19 gene and thereby contributes to the repression of Igf2
Shin et al., Gene regulation and systems biology 2013 : Our evidence also suggests that butyrate induced regional changes of histone acetylation statusin the upstream regulation domain of H19 may be related to the reduced expression of H19 and strong activation of IGF2