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IFNG — SMN1

Text-mined interactions from Literome

Comu et al., Biomaterials 2000 : TGF-beta1, IFN-gamma and cytochalasin-D increased synthesis of SMA while PDGF-BB decreased it
Gu et al., Acta Pharmacol Sin 2004 : During fibroblast-myofibroblast differentiation induced by TGF-beta1, IFN-gamma 200 microg/L markedly blocked TGF-beta1 induced alpha-SMA protein expression ( P < 0.01 ), collagen protein ( P < 0.01 ) and mRNA ( P < 0.05 ) expression, and myofibroblasts morphological transformation, but DEX 10 micromol/L augmented TGF-beta1 induced alpha-SMA expression ( P < 0.01 ). For myofibroblasts, both IFN-gamma 200 microg/L and DEX 10 micromol/L did not inhibit alpha-SMA expression ( P > 0.05 ) and collagen protein ( P > 0.05 ) and mRNA expression ( P > 0.05 ) and did not change myofibroblasts morphology
Giannopoulou et al., American journal of physiology. Renal physiology 2006 (Fibrosis...) : Blockade of Erk-1/2 activation with an Mek1 inhibitor abolished the inhibitory effect of IFN-gamma on alpha-SMA expression, whereas inhibition of Stat3 activation had no influence
Ha et al., Hepatogastroenterology 2008 : IFN-gamma exhibited a dose dependent inhibitory effect on a-SMA , collagen type I, collagen type III protein expression in HSC ( p < 0.01 ) ; also IFN-gamma implemented a dose dependent inhibitory effect on TGF-beta1, Smad4 and especially TGFBRI protein expression in HSC ( p < 0.01 )