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CTSL — IFNG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTSL → IFNG (increases) Lemaire et al., Br J Rheumatol 1997*
  Evidence: Interferon Gamma treatment of synovial fibroblast like cells led to increased secretion of Cathepsin L. The level of both cathepsin L in culture media was found to almost double at 24 hours of IFN Gamma treatment. The stimulating effect of IFN-Gamma on cathepsin secretion was optimized at a concentration of 10ng/ml with a 2.1 fold maximal increase for cathepsinL.

Text-mined interactions from Literome

Zhang et al., Biochem Biophys Res Commun 2001 : Furthermore, foreign antigens, but not self-antigens, could increase the activity of cathepsin L , probably being mediated by interferon-gamma , as demonstrated by in vivo and in vitro experiments
Nakashima et al., Chudoku Kenkyu 2002 : The production of IFN-gamma and IL-2 was inhibited by MEP in a concentration dependent manner, but GLP slightly inhibited their production only at 1000 microM
Pang et al., Biochem Biophys Res Commun 2005 : IFN-gamma stimulates both CTSL and CTSS expression after 3 days, but fails to significantly alter CTSK expression