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IFI27 — STAT5A

Text-mined interactions from Literome

Klausen et al., Oncogene 2000 : Inhibition of MEK activation completely abrogated OSM and IL-6 induced p27kip1 accumulation, while expression of dominant negative STAT5 decreased the OSM and IL-6 mediated inhibition of DNA-synthesis and partially inhibited p27kip1 accumulation
Walz et al., J Biol Chem 2006 (Cell Transformation, Neoplastic...) : Mechanisms leading to altered p27 ( Kip ) and cyclin D2 likely involve inhibition of STAT5, a major target of Jak2 in hematopoietic cells, because a constitutively active form of STAT5 reduced p27 ( Kip ) and increased cyclin D2 expression
Nakayama et al., Blood 2009 (Precursor B-Cell Lymphoblastic Leukemia-Lymphoma) : Inhibition of IL-7R signaling or JAK3/STAT5 activity resulted in the induction of p27 ( kip1 ) expression and cell-cycle arrest, accompanied by apoptosis in the leukemia cells