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FOS — PLG
Text-mined interactions from Literome
Yoshizaki et al., Histol Histopathol 2002
(Carcinoma...) :
LMP-1 down-regulates expression of E-cadherin,
induces matrix metalloproteinase-9 and urokinase
type-plasminogen activator through activation of NF-kappaB and
AP-1 , and enhances cell motility via ets-1 activation
Syrovets et al., Thromb Haemost 2002
(Inflammation) :
Ciglitazone activates PPAR gamma as shown by a novel surface plasmon resonance analysis and inhibits the
plasmin induced activation of NF-kappa B and
AP-1
Cuevas et al., Oncogene 2005
:
Both FGF-2 and phorbol ester-inducible urokinase-type
plasminogen activator ( uPA ) expression
requires AP-1 binding to an enhancer element in the uPA promoter, and we have previously shown that FGF-2 or PMA induction of uPA expression is strongly dependent on MEKK1
De Sousa et al., Biochem Biophys Res Commun 2005
(MAP Kinase Signaling System) :
Furthermore,
Plg/Pla also
stimulated AP-1 and EGR-1 DNA binding activities, which were abrogated by pharmacological inhibition of MEK
Sousa et al., Biochem Biophys Res Commun 2005
(MAP Kinase Signaling System) :
Previously we have demonstrated that both
plasminogen (Plg) and plasmin (Pla)
regulate the expression of the transcription factors
c-FOS and EGR-1 [ L.P. De Sousa, B.S. Brasil, B.M. Silva, M.H. Freitas, S.V. Nogueira, P.C. Ferreira, E.G. Kroon, C.A. Bonjardim, Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway, Biochem
Mann et al., Proc Natl Acad Sci U S A 1999
(Adenocarcinoma...) :
There are four genes affected by beta-catenin overexpression ; three overexpressed genes code for two components of the AP-1 transcription complex, c-jun and fra-1, and for the urokinase-type
plasminogen activator receptor ( uPAR ), whose transcription is
activated by
AP-1