Gene interactions and pathways from curated databases and text-mining

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FOS — PLG

Text-mined interactions from Literome

Yoshizaki et al., Histol Histopathol 2002 (Carcinoma...) : LMP-1 down-regulates expression of E-cadherin, induces matrix metalloproteinase-9 and urokinase type-plasminogen activator through activation of NF-kappaB and AP-1 , and enhances cell motility via ets-1 activation
Syrovets et al., Thromb Haemost 2002 (Inflammation) : Ciglitazone activates PPAR gamma as shown by a novel surface plasmon resonance analysis and inhibits the plasmin induced activation of NF-kappa B and AP-1
Cuevas et al., Oncogene 2005 : Both FGF-2 and phorbol ester-inducible urokinase-type plasminogen activator ( uPA ) expression requires AP-1 binding to an enhancer element in the uPA promoter, and we have previously shown that FGF-2 or PMA induction of uPA expression is strongly dependent on MEKK1
De Sousa et al., Biochem Biophys Res Commun 2005 (MAP Kinase Signaling System) : Furthermore, Plg/Pla also stimulated AP-1 and EGR-1 DNA binding activities, which were abrogated by pharmacological inhibition of MEK
Sousa et al., Biochem Biophys Res Commun 2005 (MAP Kinase Signaling System) : Previously we have demonstrated that both plasminogen (Plg) and plasmin (Pla) regulate the expression of the transcription factors c-FOS and EGR-1 [ L.P. De Sousa, B.S. Brasil, B.M. Silva, M.H. Freitas, S.V. Nogueira, P.C. Ferreira, E.G. Kroon, C.A. Bonjardim, Plasminogen/plasmin regulates c-fos and egr-1 expression via the MEK/ERK pathway, Biochem
Mann et al., Proc Natl Acad Sci U S A 1999 (Adenocarcinoma...) : There are four genes affected by beta-catenin overexpression ; three overexpressed genes code for two components of the AP-1 transcription complex, c-jun and fra-1, and for the urokinase-type plasminogen activator receptor ( uPAR ), whose transcription is activated by AP-1