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EGF — TP53

Text-mined interactions from Literome

Fang et al., EMBO J 2001 (MAP Kinase Signaling System) : HB-EGF neutralizing antibody and inhibitors of EGF receptor signaling abrogated p53 induced MAPK activation
Minter et al., Development 2002 : To determine whether steroid hormones directly modulate p53 activity, whole organ cultures of mammary glands were induced to proliferate using estrogen plus progesterone or epidermal growth factor plus transforming growth factor-alpha and p53 responses to gamma-irradiation were measured
Akca et al., Growth Factors 2003 (Uterine Cervical Neoplasms) : Since many tumors secrete growth factor ( s ) that inhibit apoptosis and support the growth of cancer cells, we investigated the effects of human epidermal growth factor (EGF) on human TNF-alpha mediated induction of p53 and its transcriptional target, p21 in TNF-alpha sensitive human cervical carcinoma cell line, ME180S ... An inhibitor of PKC, GF 109203X inhibited EGF mediated suppression of TNF-alpha induced accumulation of p53 , p21 and induction of apoptosis
Han et al., Nucleic Acids Res 1992 : The level of alternatively spliced p53 RNA was increased coordinately with that of regularly spliced p53 in 10T1/2 cells in response to epidermal growth factor
Khanal et al., Carcinogenesis 2009 (Cell Transformation, Neoplastic) : The overexpression of Tpl-2 inhibited the epidermal growth factor (EGF) induced p53 phosphorylation ( Ser15 ) through upregulating the activity of protein phosphatase 2A, which interacted with p53 stimulated by EGF ... Also, the EGF induced p53 activity was suppressed in the Tpl-2 wild-type ( WT ) -transfected HEK 293 cells, but had no effect in the Tpl-2-mutant ( S413A ) -transfected cells
Staun-Ram et al., Placenta 2009 : p53 Mediates epidermal growth factor (EGF) induction of MMP-2 transcription and trophoblast invasion ... EGF induced binding activity and expression of phophorylated p53 , AP-2alpha and -gamma, C/EBPepsilon and -lambda to their responding sequences, found in the MMP-2 promoter
Qi et al., BMC cancer 2011 (Colonic Neoplasms) : Downstream, EGF induced disassociation of FOXO3 from mutated tumor suppressor p53, but not wild type p53 , is inhibited by genistein favoring FOXO3-p53 ( mut ) interactions with the promoter of the cell cycle inhibitor p27kip1 in colon cancer cells
Prasad et al., Clin Cancer Res 2012 (Colorectal Neoplasms...) : In addition, ursolic acid suppressed EGF receptor (EGFR) and induced p53 and p21 expression
Deb et al., Oncogene 1994 : We show that wild-type human p53 transactivates the human epidermal growth factor receptor (EGFR) promoter in vivo in a dose dependent manner, implicating p53 in promotion of cell proliferation
Galbraith et al., Oncol Res 1996 (Carcinoma, Squamous Cell) : Whereas A253 cells were unresponsive to the growth-inhibitory effects of TGF-beta, EGF stimulated A253-p53 cells responded to TGF-beta with markedly reduced DNA synthetic rates
Prasad et al., Cell Prolif 1997 (Breast Neoplasms) : EGF effects on p53 in MDA-468 human breast cancer cells : implications for G1 arrest ... In this study, we report an EGF dependent altered conformation as indicated by immunofluorescence, while no significant immediate effects of EGF-treatment on p53 ( 273.His ) protein levels and synthesis were observed
Blevins et al., Oncology (Williston Park) 1998 (Adenoma...) : The expression of p53 , increased epidermal growth factor receptors, and protein kinase C activity also correlate with invasion and aggressive behavior