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EGF — PRKCA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Seth et al., Invest Ophthalmol Vis Sci 2001
:
Of several PKC isoforms investigated ( alpha, betaI, betaII, and gamma ), only
PKCalpha and betaII were significantly
activated by
EGF and inhibited by baicalein
Sylvester et al., Cell Prolif 2001
:
However, these treatments were found to inhibit
EGF induced
PKC(alpha) activation as determined by its translocation from the cytosolic to membrane fraction
Wagner et al., Molecular vision 2002
:
Both phorbol ester and
EGF caused an increased interaction of
PKCalpha with tropomodulin ... Following
activation of
PKCalpha by phorbol ester or by
EGF there was an increased phosphorylation of tropomodulin on threonine residues ...
Activation of
PKCalpha by
EGF causes an increased phosphorylation of tropomodulin which results in an increase in tropomodulin association with cytoskeletal components ... This establishes a signal pathway by which
EGF induced
activation of
PKCalpha alters the interaction of lens cytoskeletal proteins
Shih et al., Mol Cancer Ther 2004
(Prostatic Neoplasms) :
Inhibitory effect of
epidermal growth factor on resveratrol induced apoptosis in prostate cancer cells is
mediated by
protein kinase C-alpha ... An inhibitor of
protein kinase C (PKC)-alpha , -beta, and -gamma ( CGP41251 ) enhanced Ser15 phosphorylation of p53 by resveratrol in the absence of EGF and
blocked EGF inhibition of the resveratrol effect ...
EGF caused
PKC-alpha/beta phosphorylation in DU145 cells, an effect reversed by CGP41251
Sharma et al., J Biol Chem 2005
:
PD153035, a specific inhibitor of tyrosine kinase activity of the EGF receptor, completely blocked
PKCalpha translocation
induced by
EGF
Eldar et al., J Biol Chem 1990
:
Hence, our studies imply that
PKC alpha is
involved in a cellular mechanism regulating the expression of
EGF receptor molecules in Swiss/3T3 cells
Villanueva-García et al., Exp Lung Res 2007
:
EGF , but not TGFalpha,
stimulated PKCalpha activation and membrane translocation
Maloney et al., Am J Physiol 1998
:
In contrast, both ANG II and
EGF induced only a minor translocation of
PKC-alpha to the membrane fraction but caused a statistically significant membrane directed movement of PKC-delta and -epsilon